Results 91 to 100 of about 96,362 (287)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Lifestyle InterVention IN Gestational diabetes (LIVING) in India, Bangladesh and Sri Lanka: protocol for process evaluation of a randomised controlled trial

BMJ Open, 2020
Introduction The development of type 2 diabetes mellitus disproportionately affects South Asian women with prior gestational diabetes mellitus (GDM). The Lifestyle InterVention IN Gestational diabetes (LIVING) Study is a randomised controlled trial of a ...
Anushka Patel, Stephen Jan, Rohina Joshi, Devarsetty Praveen, Nikhil Tandon, Helena J Teede, Deksha Kapoor, Lakshmi K Josyula, Yashdeep Gupta, Ankush Desai   +9 more
doaj   +1 more source

Evidence of a spectral break in the gamma-ray emission of the disk component of Large Magellanic Cloud: a hadronic origin?

, 2017
It has been suggested that high-energy gamma-ray emission ($>100{\rm MeV}$) of nearby star-forming galaxies may be produced predominantly by cosmic rays colliding with the interstellar medium through neutral pion decay.
Liu, Ruo-Yu, Peng, Fang-Kun, Tam, Pak-Hin Thomas, Tang, Qing-Wen, Wang, Xiang-Yu   +4 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Studying the X-ray hysteresis in GX 339-4: the disc and iron line over one decade

, 2008
We report on a comprehensive and consistent investigation into the X-ray emission from GX 339-4. All public observations in the 11 year RXTE archive were analysed.
Belloni T., C. Cabanac, Corbel S., E. G. Körding, Fender R. P., George I. M., Miniutti G., R. J. H. Dunn, R. P. Fender, Sunyaev R., T. Belloni, Ueda Y.   +11 more
core   +2 more sources

Absolute intensity normalization of powder neutron scattering data

Journal of Applied Crystallography
An important property of neutron diffraction data is that they can be normalized in absolute intensity units. In practice, however, such normalization is seldom performed, since it can be time consuming and subject to systematic uncertainties. Here, a straightforward approach is presented for absolute intensity normalization of neutron diffraction data
openaire   +2 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

УПРАВЛЕНИЕ МИКРОЭКОЛОГИЕЙ ОРГАНИЗМА ПРОДУКТИВНЫХ ЖИВОТНЫХ - АЛЬТЕРНАТИВНЫЙ МЕТОД ОЗДОРОВЛЕНИЯ И ОБЕСПЕЧЕНИЯ ПРОДОВОЛЬСТВЕННОЙ БЕЗОПАСНОСТИ

Ветеринарная патология, 2007
Safe alternative to antibiotics for prevention and treatment of calfs gastroenteric frustration has become an application of lactic and other normoflores bacteria in probiotics form for prophylaxis, termination or simplification of diarrheas. The article

doaj  

Efficacy and safety of high-intensity electromagnetic stimulation in the prevention of recurrence of rectocele after surgical treatment

Клинический разбор в общей медицине
The etiology of rectocele is diverse and can be caused by gynaecological and extragenital diseases, but the exact mechanisms of formation of anatomical, functional defects of the pelvic floor and methods of effective treatment from the position of ...
Mekan R. Orazov, Viktor E. Radzinsky, Elena S. Silantieva , Farida F. Minnullina, Roman E. Orekhov, Anastasia E. Pavlova   +5 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source