Results 71 to 80 of about 96,362 (287)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
BMC Medical Imaging, 2012 Background SPECT/CT combines high resolution anatomical 3D computerized tomography (CT) and single photon emission computerized tomography (SPECT) as functional imaging, which provides 3D information about biological processes into a single imaging ...
Hirschmann Michael T +3 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
BMC Bioinformatics, 2005 Background: Biological Mass Spectrometry is used to analyse peptides and proteins. A mass spectrum generates a list of measured mass to charge ratios and intensities of ionised peptides, which is called a peak-list.
Gobom Johan +8 more
doaj +1 more source
Iron-line and continuum variations in the XMM-Newton and Suzaku spectra of the neutron-star low-mass X-ray binary 4U 1636-53 [PDF]
, 2014 We used six simultaneous XMM-Newton and Rossi X-ray Timing Explorer plus five Suzaku observations to study the continuum spectrum and the iron emission line in the neutron-star low-mass X-ray binary 4U 1636-53.
Belloni, Tomaso +5 more
core +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Tandem mass spectrometry data quality assessment by self-convolution
BMC Bioinformatics, 2007 Background Many algorithms have been developed for deciphering the tandem mass spectrometry (MS) data sets. They can be essentially clustered into two classes.
Tham Wai, Choo Keng
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Deep radio observations of the radio halo of the bullet cluster 1E 0657-55.8 [PDF]
, 2014 We present deep 1.1-3.1 GHz Australia Telescope Compact Array observations of the radio halo of the bullet cluster, 1E 0657-55.8. In comparison to existing images of this radio halo the detection in our images is at higher significance. The radio halo is
Brown, Shea +5 more
core +3 more sources