Results 71 to 80 of about 16,736 (246)

Efficacy and safety of high-intensity electromagnetic stimulation in the prevention of recurrence of rectocele after surgical treatment

Клинический разбор в общей медицине
The etiology of rectocele is diverse and can be caused by gynaecological and extragenital diseases, but the exact mechanisms of formation of anatomical, functional defects of the pelvic floor and methods of effective treatment from the position of ...
Mekan R. Orazov, Viktor E. Radzinsky, Elena S. Silantieva , Farida F. Minnullina, Roman E. Orekhov, Anastasia E. Pavlova   +5 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Absolute intensity normalization of powder neutron scattering data

Journal of Applied Crystallography
An important property of neutron diffraction data is that they can be normalized in absolute intensity units. In practice, however, such normalization is seldom performed, since it can be time consuming and subject to systematic uncertainties.
openaire   +2 more sources

Contrast-Enhanced Ultrasound to Assess Kidney Quality During Ex Situ Normothermic Machine Perfusion

Transplant International
Normothermic machine perfusion (NMP) provides opportunity for viability assessment of donated kidneys. Diminished microvascular perfusion, despite adequate total blood flow, is a key pathophysiology in ischaemia-mediated acute kidney injury.
Samuel J. Tingle, Samuel J. Tingle, Samuel J. Tingle, Chloe Connelly, Emily K. Glover, Emily K. Glover, Emily K. Glover, Ben Stenberg, Andrew McNeill, Georgios Kourounis, Georgios Kourounis, Georgios Kourounis, Beth G. Gibson, Balaji Mahendran, Balaji Mahendran, Balaji Mahendran, Lucy Bates, Lucy Bates, Madison N. Cooper, Madison N. Cooper, Rhys R. Pook, Rhys R. Pook, Samantha Lee, Samantha Lee, Marnie L. Brown, Marnie L. Brown, Rodrigo Figueiredo, Kevin J. Marchbank, Kevin J. Marchbank, Simi Ali, Simi Ali, Neil S. Sheerin, Neil S. Sheerin, Neil S. Sheerin, Colin H. Wilson, Colin H. Wilson, Colin H. Wilson, Emily R. Thompson, Emily R. Thompson, Emily R. Thompson   +39 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Dual-Detector Vision and Depth-Aware Back-Projection for Accurate Apple Detection and 3D Localisation for Robotic Harvesting

Robotics
Accurate apple detection and precise three-dimensional (3D) localisation are essential for autonomous robotic harvesting in orchard environments, where occlusion, illumination variation, depth noise, and the similar colour appearance of fruits and ...
Tagor Hossain, Peng Shi, Levente Kovacs
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Implementing palliative care in intensive care units: assessing processes using the normalisation process theory NoMAD instrument

Implementation Science Communications
Abstract Background The importance of palliative care for Intensive Care Unit (ICU) patients/families is known. Little is known about implementing this care in practice, and how to support healthcare professionals in this implementation.
Stephanie A. Meddick-Dyson, Tracy Finch, Jason W. Boland, Mark Pearson, Andy Bradshaw, Fliss E. M. Murtagh   +5 more
openaire   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source