Results 71 to 80 of about 3,925,241 (306)

Gender analysis of vulnerability of smallholder farming households to climate variability and change in North-central Nigeria

Agricultura Tropica et Subtropica, 2021
The frequency and intensity of climatic variables as indicators of climate change have been increasingly recognised as global crisis with significant impact on biodiversity, household food security and gender roles.
Daudu Abdulrazaq Kamal, Salami Oluwashola Shakirat, Kareem Oyedola Waheed   +2 more
doaj   +1 more source

AI-driven software for automated quantification of skeletal metastases and treatment response evaluation using whole-body diffusion-weighted MRI (WB-DWI) in advanced prostate cancer [PDF]

Physics in Medicine and Biology
Objective. Quantitative assessment of treatment response in advanced prostate cancer (APC) with bone metastases remains an unmet clinical need. Whole-body diffusion-weighted MRI (WB-DWI) provides two response biomarkers: total diffusion volume (TDV) and ...
Antonio Candito, M. Blackledge, Richard Holbrey, Nuria Porta, A. Ribeiro, F. Zugni, Luca D'Erme, F. Castagnoli, Alina Dragan, R. Donners, C. Messiou, N. Tunariu, D.-M. Koh   +12 more
semanticscholar   +1 more source

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy

NeuroImage: Clinical, 2017
Focal cortical dysplasia is a congenital abnormality of cortical development and the leading cause of surgically remediable drug-resistant epilepsy in children.
Sophie Adler, Konrad Wagstyl, Roxana Gunny, Lisa Ronan, David Carmichael, J Helen Cross, Paul C. Fletcher, Torsten Baldeweg   +7 more
doaj   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source

Two Decades of Free Movement: Assessing the Socio-Economic Factors of Emigration in Latvia

Economies
Emigration remains an important socio-economic challenge for Latvia, affecting labour market development, human capital availability, and long-term economic growth prospects.
Anastasija Romāne, Astra Auziņa-Emsiņa, Iveta Mietule   +2 more
doaj   +1 more source

Investigating the implementation of a complex intervention to reduce central line-associated bloodstream infections in the Neonatal Intensive Care Unit, using Normalisation Process Theory [PDF]

Journal of Neonatal Nursing
Abstract Background Translating evidence into practice has been notoriously difficult within the field of infection prevention and control (IPC). Care bundles- a form of complex intervention with multiple interacting components, may reduce neonatal CLABSIs by 60%. However, it may be unclear if it is the bundle, the implementation process, or a
Victoria Payne, Mark J Johnson, Katherine Hunt, Jacqui Prieto   +3 more
openaire   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Intrinsic noise of a superheated droplet detector for neutron background measurements in massively shielded facilities

EPJ Web of Conferences, 2017
Superheated droplet detectors are a promising technique to the measurement of low-intensity neutron fields, as detectors can be rendered insensitive to minimum ionizing radiations.
Fernandes Ana C., Morlat Tomoko A., Felizardo Miguel, Kling Andreas, Marques José G., Prudêncio Maria I., Marques Rosa, Carvalho Fernando P., Roche Ignácio Lázaro, Girard Thomas A.   +9 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source