Results 51 to 60 of about 96,362 (287)

Improving the Evaluation and Management of Transfusion‐Related Iron Overload in Children, Adolescents, and Young Adults Following Cancer Treatment or Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell, Allison Close, Guoli Zhou, Troy C. Quigg   +3 more
wiley   +1 more source

The Reliability of Electromyographic Normalization Methods for Cycling Analyses [PDF]

, 2015
Electromyography (EMG) is normalized in relation to a reference maximum voluntary contraction (MVC) value. Different normalization techniques are available but the most reliable method for cycling movements is unknown.
Ball, Benoit, Burden, Cram, Darrell Brooks, Howard Thomas Hurst, Jack Hebron, Jonathan Sinclair, Lehman, Miller, Netto, Paul John Taylor, Sauer, Sinclair, Stephen Atkins   +14 more
core   +2 more sources

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Longitudinal Voxel-based morphometry with unified segmentation: evaluation on simulated Alzheimer’s disease [PDF]

, 2007
The goal of this work is to evaluate Voxel-Based Morphometry and three longitudinally-tailored methods of VBM.We use a cohort of simulated images produced by deforming original scans using a Finite Element Method, guided to emulate Alzheimer-like ...
Camara, O., Crum, W.R., Fox, N.C., Hill, D.L.G., Ridgway, G.R., Scahill, R.I., Whitcher, B.   +6 more
core  

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Novel surface features for automated detection of focal cortical dysplasias in paediatric epilepsy

NeuroImage: Clinical, 2017
Focal cortical dysplasia is a congenital abnormality of cortical development and the leading cause of surgically remediable drug-resistant epilepsy in children.
Sophie Adler, Konrad Wagstyl, Roxana Gunny, Lisa Ronan, David Carmichael, J Helen Cross, Paul C. Fletcher, Torsten Baldeweg   +7 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Fermi Bubbles and Bubble-like emission from the Galactic Plane

, 2014
The diffuse gamma-ray sky revealed 'Bubbles' of emission above and below the Galactic Plane symmetric around the centre of the Milky Way with a height of 10 kpc in both directions. At present there is no convincing explanation for the origin.
de Boer, Wim, Weber, Markus
core   +1 more source

Doppler-free laser spectroscopy of buffer gas cooled molecular radicals [PDF]

, 2009
We demonstrate Doppler-free saturated absorption spectroscopy of cold molecular radicals formed by laser ablation inside a cryogenic buffer gas cell. By lowering the temperature, congested regions of the spectrum can be simplified, and by using different
Hendricks, R. J., Hinds, E. A., Hudson, J. J., Sauer, B. E., Segal, D. M., Sinclair, C. D. J., Skoff, S. M., Tarbutt, M. R.   +7 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source