Results 81 to 90 of about 96,362 (287)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Comparison of the determination of a low-concentration active ingredient in pharmaceutical tablets by backscatter and transmission raman spectrometry [PDF]

, 2012
A total of 383 tablets of a pharmaceutical product were analyzed by backscatter and transmission Raman spectrometry to determine the concentration of an active pharmaceutical ingredient (API), chlorpheniramine maleate, at the 2% m/m (4 mg) level.
Andrews, John, Dallin, Paul, Littlejohn, David, Myrick, Michael, Nordon, Alison, Townshend, Nichola   +5 more
core   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

A decade of winter supraglacial lake drainage across Northeast Greenland using C-band SAR [PDF]

The Cryosphere
This study presents a comprehensive, multi-year assessment of winter supraglacial lake drainages on the Northeast Greenland Ice Sheet, detailing cascading drainage events, in which drainage of one lake triggers a chain of subsequent drainages that often ...
C. W. Dean, R. Scharien, I. Willis, K. A. McDougall   +3 more
doaj   +1 more source

Retrofit Poverty: Socioeconomic Spatial Disparities in Retrofit Subsidies Uptake

Buildings & Cities, 2020
Framed in the concept of distributional justice, retrofit poverty may be understood as the inequality of opportunity to improve the energy performance of the home.
Nicola Willand, Trivess Moore, Ralph Horne, Sarah Robertson   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Interpolation-split: a data-centric deep learning approach with big interpolated data to boost airway segmentation performance

Journal of Big Data
The morphology and distribution of airway tree abnormalities enable diagnosis and disease characterisation across a variety of chronic respiratory conditions.
Wing Keung Cheung, Ashkan Pakzad, Nesrin Mogulkoc, Sarah Helen Needleman, Bojidar Rangelov, Eyjolfur Gudmundsson, An Zhao, Mariam Abbas, Davina McLaverty, Dimitrios Asimakopoulos, Robert Chapman, Recep Savas, Sam M. Janes, Yipeng Hu, Daniel C. Alexander, John R. Hurst, Joseph Jacob   +16 more
doaj   +1 more source

Single/Few Bunch Space Charge Effects at 8-GeV in the Fermilab Main Injector [PDF]

, 2012
For Project X, it is planned to inject a beam of 3x10**11 particles per bunch into the Main Injector. Therefore, at 8-GeV, there will be increased space charge tune shifts and an increased incoherent tune spread. In preparation for these higher intensity
Capista, D., Kourbanis, I., Scott, D. J., Seiya, K., Yang, M. -J.   +4 more
core   +1 more source

XMM-Newton 13H Deep field - I. X-ray sources

, 2005
We present the results of a deep X-ray survey conducted with XMM-Newton, centred on the UK ROSAT 13H deep field area. This region covers 0.18 deg^2 and is the first of two areas covered with XMM-Newton as part of an extensive multi-wavelength survey ...
A. M. Newsam, Akiyama, Alexander, Alexander, Antonucci, Baldi, Barger, Barger, Barger, Bauer, Brandt, Cagnoni, Carrera, Cash, Comastri, Comastri, Condon, Cowie, D. Moss, De Luca, Della, Eddington, F. Cordova, Fiore, Fiore, Gendreau, Georgantopoulos, Giacconi, Giacconi, Giedke, Gilli, Gilli, Gilli, Giommi, Gunn, Hasinger, Hasinger, Hasinger, I. McHardy, Ishisaki, K. Gunn, K. Mason, K. Sekguchi, Lamer, Lehmann, Loaring, Lumb, M. J. Page, Maccacaro, Mainieri, Maiolino, Manners, Marshall, Mason, Mateos, McHardy, McHardy, Murdoch, Mushotzky, N. S. Loaring, N. Seymour, Page, Page, Rosati, Schmidt, Schwartz, Seymour, Shanks, Szokoly, T. Dwelly, T. Sasseen, T. Takata, Teerikorpi, Tozzi, Turner, Ueda, Ueda, Ueda, Ueda, Vecchi, Voges, Yang, Yang, Zamorani   +83 more
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source