Results 81 to 90 of about 3,925,241 (306)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

A Randomised, Controlled Study of Different Glycaemic Targets during Gestational Diabetes Treatment: Effect on the Level of Adipokines in Cord Blood and ANGPTL4 Expression in Human Umbilical Vein Endothelial Cells

International Journal of Endocrinology, 2018
Our aim was to study the expression of adipokine-encoding genes (leptin, adiponectin, and angiopoietin-like protein 4 (ANGPTL4)) in human umbilical vein endothelial cells (HUVECs) and adipokine concentration in cord blood from women with gestational ...
P. Popova, L. Vasilyeva, A. Tkachuck, M. Puzanov, A. Golovkin, Y. Bolotko, E. Pustozerov, E. Vasilyeva, O. Li, I. Zazerskaya, R. Dmitrieva, A. Kostareva, E. Grineva   +12 more
doaj   +1 more source

E-commerce Orientation and Post-Pandemic Recovery: Evidence from Polish Textile Firms Listed on the Warsaw Stock Exchange

Forum Scientiae Oeconomia
This research analyses the financial resilience of Polish textile and clothing firms listed on the Warsaw Stock Exchange (GPW) during the period of the pandemic known as the “COVID-19 shock” and the subsequent recovery.
Tomasz Czajkowski, Sergio Luis Nanez Alonso, Ricardo Reier Forradellas, Anna Bacciarelli-Ulacha   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

The Five Accomplishments: A Framework for Obtaining Customer Feedback in a Health Service Community Learning Disability Team [PDF]

, 1998
The usefulness of using the philosophy of normalisation and, in particular, O`Brien`s (1992) Five Accomplishments as a basis for evaluating client satisfaction with a community based health service learning disabilities team was examined.
Kidd, Gill, Sinclair, Bridget, Lakhani, Shradha, McKenzie, Karen, Murray, George, Bridget Sinclair, Shradha LakhaniAssistant Psychologist, Karen McKenzie, George C. Murray, Gillian R. Kidd   +9 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Interpolation-split: a data-centric deep learning approach with big interpolated data to boost airway segmentation performance

Journal of Big Data
The morphology and distribution of airway tree abnormalities enable diagnosis and disease characterisation across a variety of chronic respiratory conditions.
Wing Keung Cheung, Ashkan Pakzad, Nesrin Mogulkoc, Sarah Helen Needleman, Bojidar Rangelov, Eyjolfur Gudmundsson, An Zhao, Mariam Abbas, Davina McLaverty, Dimitrios Asimakopoulos, Robert Chapman, Recep Savas, Sam M. Janes, Yipeng Hu, Daniel C. Alexander, John R. Hurst, Joseph Jacob   +16 more
doaj   +1 more source

Standardized volumetric 3D-analysis of SPECT/CT imaging in orthopaedics: overcoming the limitations of qualitative 2D analysis

BMC Medical Imaging, 2012
Background SPECT/CT combines high resolution anatomical 3D computerized tomography (CT) and single photon emission computerized tomography (SPECT) as functional imaging, which provides 3D information about biological processes into a single imaging ...
Hirschmann Michael T, Wagner Christopher R, Rasch Helmut, Henckel Johann   +3 more
doaj   +1 more source

A role for eIF5A in translational control of stress‐inducible proteins in multiple myeloma cell lines

Molecular Oncology, EarlyView.
Loss of eIF5A rewires thapsigargin‐mediated endoplasmic reticulum stress responses in multiple myeloma cells by selective translation of mRNA transcripts, consequently dampening thapsigargin‐induced unfolded protein response (UPR) activation and shifting the balance from induction of apoptosis toward cell survival and proliferation.
Demi Both, Ingrid A. M. Derks, Raphaël Vanleyssem, Marine Leclercq, Najla El Hachem, Pierre Close, Eric Eldering, Marco Vincent Haselager   +7 more
wiley   +1 more source