Results 111 to 120 of about 7,689,168 (361)
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Evidence-based implementation practices applied to the intensive treatment of eating disorders: Summary of research and illustration of principles using a case example [PDF]
, 2018 Implementation of evidence‐based practices (EBPs) in intensive treatment settings poses a major challenge in the field of psychology. This is particularly true for eating disorder (ED) treatment, where multidisciplinary care is provided to a severe and ...
Barlow, David H. +11 more
core +1 more source
Predicting Intensive Care Unit Readmission with Machine Learning Using Electronic Health Record Data
Annals of the American Thoracic Society, 2018 &NA; Rationale: Patients transferred from the intensive care unit to the wards who are later readmitted to the intensive care unit have increased length of stay, healthcare expenditure, and mortality compared with those who are never readmitted ...
J. C. Rojas +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
UCH-L1 Inhibitor Alleviates Nerve Damage Caused by Moyamoya Disease
Applied Bionics and BiomechanicsBackground. Moyamoya disease (MMD) leads to nerve injury. Exosomes are touted as bio-shuttles for the delivery of distinct biomolecules inside the cells. Recently, UCH-L1 was shown to play a vital role in nerve injury.
Minghua Xu +10 more
doaj +1 more source
Long-stay patients in pediatric intensive care unit: Diagnostic-specific definition and predictors.
PLoS ONE, 2019 AIMS:To stipulate a new definition for long-stay patients (LSPs) in pediatric intensive care unit (PICU). We defined LSPs as the 10% of patients with the longest PICU length-of-stay (LOS) for each age and diagnostic group.
Angelo Polito +4 more
doaj +1 more source
Assessment of Signal Processing Methods for Measuring the Respiratory Rate in the Neonatal Intensive Care Unit [PDF]
, 2019 João Jorge +5 more
openalex +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Case Reports in EndocrinologyHyperosmolar hyperglycemic state (HHS) is a life-threatening condition characterized by extreme hyperglycemia, high plasma osmolality, and severe dehydration without significant ketoacidosis.
Arnaud Robert +5 more
doaj +1 more source