Results 51 to 60 of about 1,303,394 (303)

Body weight definitions for evaluating a urinary diagnosis of acute kidney injury in patients with sepsis

BMC Nephrology, 2018
Background We hypothesized that the use of actual body weight might lead to more frequent misdiagnosis of acute kidney injury (AKI) than when ideal body weight is used in underweight and/or obese patients.
Shinshu Katayama, Kansuke Koyama, Yuya Goto, Toshitaka Koinuma, Ken Tonai, Jun Shima, Masahiko Wada, Shin Nunomiya   +7 more
doaj   +1 more source

Covid-19 in China: ten critical issues for intensive care medicine

Critical Care, 2020
In December 2019, a newly identified coronavirus (SARS-CoV-2) major outbreak appeared in Wuhan City, Hubei Province, and it is now termed the Covid-19. The SARS-CoV-2 infection moved rapidly through China [1, 2] and spread to more than 90 countries.
Li Li, S. Gong, Jing Yan
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Esophageal Achalasia: An Unusual Cause of Respiratory Distress

Case Reports in Critical Care
Esophageal achalasia is a rare condition affecting both men and women. It is a motility disorder of the esophagus resulting in the lack of relaxation of the lower sphincter, yielding to food stasis.
Océane Thiry, Marion Schaefer, Aurélie Cravoisy, Lionel Nace, Thibault François, Jacques Allard, Sébastien Gibot   +6 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

Molecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima, Yuko Takami, Ken Kawabe, Kazuhiro Tanabe, Chihiro Hayashi, Mikio Mikami, Tetsuya Kusumoto   +6 more
wiley   +1 more source

COVID-19 related acute necrotizing encephalopathy and acute myocarditis in an adult female: a novel case report of brain injury and myocarditis

BMC Neurology
Background Acute necrotizing encephalopathy (ANE) and myocarditis are both acute, life-threatening conditions that can be triggered by COVID-19. We report a case of sequential ANE and myocarditis following a COVID-19 infection.
Chang Xu, Yuyi Sha, Jianneng Pan, Tao Pan, Xiaoyang Zhou, Hua Wang, Zhaojun Xu, Bixin Chen   +7 more
doaj   +1 more source

Characterization of Transverse Aortic Constriction in Mice Based on the Specific Recruitment of Leukocytes to the Hypertrophic Myocardium and the Aorta Ascendens

Mediators of Inflammation, 2021
Transverse aortic constriction (TAC) is a model that mimics pressure overload-induced left ventricular (LV) hypertrophy in mice. Alterations in immune cell functionality can promote cardiac and vascular remodeling.
Jan Lukas Kleiner, Odilia Köpke, Anton Faron, Yunyang Zhang, Jan Cornelssen, Mark Coburn, Stilla Frede, Lars Eichhorn, Christina Katharina Weisheit   +8 more
doaj   +1 more source

Gastrointestinal dysfunction in the critically ill: a systematic scoping review and research agenda proposed by the Section of Metabolism, Endocrinology and Nutrition of the European Society of Intensive Care Medicine

Critical Care, 2020
Background Gastrointestinal (GI) dysfunction is frequent in the critically ill but can be overlooked as a result of the lack of standardization of the diagnostic and therapeutic approaches.
A. Reintam Blaser, J. Preiser, Sonja Fruhwald, Alexander Wilmer, J. Wernerman, C. Benstoem, M. Casaer, Joel Starkopf, A. V. van Zanten, O. Rooyackers, Stephan M. Jakob, C. Loudet, D.E. Bear, G. Elke, M. Kott, I. Lautenschläger, Jörn Schäper, J. Gunst, Christian Stoppe, Leda Nobile, Valentin Fuhrmann, Mette M. Berger, H. O. Oudemans-van Straaten, Yaseen M. Arabi, A. Deane, Annika Jean-Charles Sonja Alexander Jan Carina Michael P. Reintam Blaser Preiser Fruhwald Wilmer Wernerman B, A. Reintam Blaser, J. Preiser, Sonja Fruhwald, Alexander Wilmer, J. Wernerman, C. Benstoem, M. Casaer, Joel Starkopf, A. V. van Zanten, O. Rooyackers, Stephan M. Jakob, C. Loudet, D.E. Bear, G. Elke, M. Kott, I. Lautenschläger, Jörn Schäper, J. Gunst, Christian Stoppe, Leda Nobile, Valentin Fuhrmann, Mette M. Berger, H. O. Oudemans-van Straaten, Yaseen M. Arabi, Adam Dean, K. Amrein, G. Besch, Brenno Belazi Nery de Souza Campos, E. de Waele, V. Fraipont, Teodoro Grau, Kursat Gundogan, C. Heidegger, M. Hiesmayr, C. Ichai, M. Juan-Díaz, Kurt Købke-Jacobsen, V. Koutsoukou, M. Laube, J. C. Montejo González, Z. Puthucheary, A. Rousseau, P. Singer, S. Stapel, H. Tekguc, Carlos Torruco-Sotelo   +71 more
semanticscholar   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source