Results 51 to 60 of about 1,093,914 (301)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Predictive factors for severe long-term chronic kidney disease after acute kidney injury requiring renal replacement therapy in critically ill patients: an ancillary study of the ELVIS randomized controlled trial

Critical Care, 2022
Background Acute kidney injury (AKI) requiring renal replacement therapy (RRT) is a serious complication in the ICU that results in increased mortality and risk of chronic kidney disease (CKD). Some studies suggest RRT modality may have an impact on long-
Edouard Soum, Jean-François Timsit, Stephane Ruckly, Didier Gruson, Emmanuel Canet, Kada Klouche, Laurent Argaud, Maïté Garrouste-Orgeas, Christophe Mariat, François Vincent, Sophie Cayot, Michael Darmon, Julien Bohé, Carole Schwebel, Lila Bouadma, Claire Dupuis, Bertrand Souweine, Alexandre Lautrette   +17 more
doaj   +1 more source

Antidepressant Use and Depressive Symptoms in Intensive Care Unit Survivors [PDF]

, 2017
Nearly 30% of intensive care unit (ICU) survivors have depressive symptoms 2-12 months after hospital discharge. We examined the prevalence of depressive symptoms and risk factors for depressive symptoms in 204 patients at their initial evaluation in the
Boustani, Malaz, Gao, Sujuan, Khan, Babar, Khan, Sikandar, Kheir, You Na, Kirk, Kayla, Lasiter, Sue, Mosher, Chris, Wang, Sophia   +8 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

The Effectiveness of Bevacizumab in COVID-19 Pneumonia Among Critically Ill Patients

Egyptian Journal of Critical Care Medicine, 2022
Background Bevacizumab, an antiangiogenic drug, is being evaluated for the management of novel coronavirus disease (COVID-19) pneumonia among critically ill patients.
Karthikkeyan Rajachandran, Giphy Susan Varghese, J. Vinoth Kumar, Santhosh Raja, S. K. Jagadish Chandran, M. Aruloli, A. Murali   +6 more
doaj   +1 more source

Family care in intensive care units

Southern African Journal of Critical Care, 2019
No Abstract.
openaire   +5 more sources

Impact of Morbidity and Mortality Conferences on Analysis of Mortality and Critical Events in Intensive Care Practice [PDF]

, 2010
Background Morbidity and mortality conferences are a tool for evaluating care management, but they lack a precise format for practice in intensive care units.Objectives To evaluate the feasibility and usefulness of regular morbidity and mortality ...
A. Novara, C. Faisy, G. Heraud, H. Ksouri, I. Abboud, J.M. Tadié, J.Y. Fagon, N. Lerolle, P.Y. Balanant   +8 more
core   +4 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source