Results 51 to 60 of about 969,027 (312)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

NURSING ATTENTION DEMANDS AT A NEONATAL, PEDIATRIC AND GENERAL INTENSIVE CARE UNIT

Cogitare Enfermagem, 2015
Descriptive and quantitative study to identify intensive nursing attention demands and the efforts these professionals make to cope with these demands.
Danilo Marcelo Araujo dos Santos, Francisca Georgina Macedo de Sousa, Thaís Marques Moreira, Andréa Cristina Oliveira Silva, Lorena Carvalho Braga   +4 more
doaj   +1 more source

Familycentred care in intensive care units

Southern African Journal of Critical Care, 2018
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P J Jordan
doaj   +1 more source

End of Life Care Practices for Patients Who Die in Intensive Care Units (ICU) [PDF]

, 2017
Today, one in five hospital deaths happens in the intensive care unit with the expectation of twice as many by 2030. Increasing, mortality has triggered a growing attention to end-of-life (EOL) care in the ICU.
Ghabeljoo, Jila
core   +1 more source

The BRACELET Study: surveys of mortality in UK neonatal and paediatric intensive care trials. [PDF]

, 2010
BACKGROUND: The subject of death and bereavement in the context of randomised controlled trials in neonatal or paediatric intensive care is under-researched.
Allen, Elizabeth, Brocklehurst, Peter, Elbourne, Diana, Harvey, Sheila E, Platt, Martin P Ward, Snowdon, Claire, Tasker, Robert C   +6 more
core   +3 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Abdominal physical examinations in early stages benefit critically ill patients without primary gastrointestinal diseases: a retrospective cohort study

Frontiers in Medicine
BackgroundGastrointestinal (GI) function is critical for patients in intensive care units (ICUs). Whether and how much critically ill patients without GI primary diseases benefit from abdominal physical examinations remains unknown.
Xiao Cui, Yu Shi, Xinlei He, Mingyuan Zhang, Hua Zhang, Jianhong Yang, Yuxin Leng   +6 more
doaj   +1 more source

Pitfalls in the Diagnosis and Management of Invasive Pneumococcal Meningoencephalitis – What We Can Learn From a Case

Clinical Medicine Insights: Case Reports, 2017
Invasive pneumococcal meningitis is a life-threatening infectious disease affecting the central nervous system. It continues to be the most common type of community-acquired acute bacterial meningitides.
Pascale S Grzonka, Raoul Sutter
doaj   +1 more source

Does early tracheostomy affect the duration of mechanical ventilation in patients with severe traumatic head injuries?

The Egyptian Journal of Otolaryngology, 2018
Background and purpose Tracheostomy is a surgical procedure performed frequently in intensive care units (ICUs). Prolonged mechanical ventilation (MV) is the main indication for tracheostomy in ICUs.
M. M. Roushdy, H. S. Abdel-Ghaffar, Ahmed Ezzat Mohamed Saleh   +2 more
doaj   +1 more source