Results 51 to 60 of about 984,139 (354)

Offline Safe Reinforcement Learning for Sepsis Treatment: Tackling Variable-Length Episodes with Sparse Rewards

Human-Centric Intelligent Systems
In critical medicine, data-driven methods that assist in physician decisions often require accurate responses and controllable safety risks. Most recent reinforcement learning models developed for clinical research typically use fixed-length and very ...
Rui Tu, Zhipeng Luo, Chuanliang Pan, Zhong Wang, Jie Su, Yu Zhang, Yifan Wang   +6 more
doaj   +1 more source

Can hypnosis and virtual reality reduce anxiety, pain and fatigue among patients who undergo cardiac surgery: a randomised controlled trial

Trials, 2020
Background Different non-pharmacological techniques, including hypnosis and virtual reality (VR) are currently used as complementary tools in the treatment of anxiety, acute and chronic pain.
Floriane Rousseaux, Marie-Elisabeth Faymonville, Anne-Sophie Nyssen, Nadia Dardenne, Didier Ledoux, Paul B. Massion, Audrey Vanhaudenhuyse   +6 more
doaj   +1 more source

Trends and Variation in End-of-Life Care for Medicare Beneficiaries With Severe Chronic Illness [PDF]

, 2011
Provides an updated analysis of regional and hospital variations in end-of-life care for Medicare beneficiaries with chronic illnesses, including percentage of hospital deaths, days in intensive care units, and physician labor per ...
Amos R. Esty, Chiang-hua Chang Phd, David C. Goodman, Elliott S. Fisher, Kristen K. Bronner   +4 more
core   +1 more source

Burden of disease and change in practice in Critically Ill Infants with Bronchiolitis [PDF]

, 2017
Bronchiolitis represents the most common cause of non-elective admission to paediatric intensive care units (ICUs)
, Australian & New Zealand Intensive Care Society (ANZICS) Centre, , Australian & New Zealand Intensive Care Society (ANZICS) Paediat, Alexander, Janet, Beca, John, Croston, Elizabeth, Erickson, Simon, Franklin, Donna, Ganu, Subodh, Gelbart, Ben, Schibler, Andreas, Schlapbach, Luregn J., Slater, Anthony, Straney, Lahn, Whitty, Jennifer A., Wilkins, Barry   +14 more
core   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

High-frequency power of heart rate variability can predict the outcome of thoracic surgical patients with acute respiratory distress syndrome on admission to the intensive care unit: a prospective, single-centric, case-controlled study

BMC Anesthesiology, 2018
Background The morbidity and mortality of acute respiratory distress syndrome (ARDS) remains high, and the strategic focus of ARDS research has shifted toward identifying patients at high risk of mortality early in the course of illness.
I-Chen Chen, Chew-Teng Kor, Ching-Hsiung Lin, Jane Kuo, Jang-Zern Tsai, Wen-Je Ko, Cheng-Deng Kuo   +6 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

End of Life Care Practices for Patients Who Die in Intensive Care Units (ICU) [PDF]

, 2017
Today, one in five hospital deaths happens in the intensive care unit with the expectation of twice as many by 2030. Increasing, mortality has triggered a growing attention to end-of-life (EOL) care in the ICU.
Ghabeljoo, Jila
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source