The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
’The Book of Stars’: Some Alternative Insights into Celebrity Fandom [PDF]
, 2008 While consumers have had a keen interest in the works and private lives of celebrities since the dawn of the Hollywood star system in the early 1920s, some consumers experience a significantly more intensive level of interest and admiration for a ...
Whelan, Susan, Wohlfeil, Markus
core
The Development of Supplementary Book Based on Direct Reading Thinking Activities to Increase the Intensive Reading Learning Outcomes [PDF]
, 2018 Rizki Agnestria, Kisyani Laksono
openalex +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
On Cultivating College Students’ Critical Thinking Ability in Intensive Reading Course
, 2021 Xiaoyan Li
openalex +1 more source
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
The Effect of Smartphone Use on Students' Intensive Reading Achievement
, 2022 Tuminah, Julis
openalex +2 more sources
The Degrees of Practicing Intensive English Language Reading Comprehension Skills by Eleventh Grade Students in the Directorate of Education in Irbid Kasbah District from Their Points of View [PDF]
, 2020 Helah Aref Harafsheh +2 more
openalex +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Graduate Catalog, 1969-1970 [PDF]
, 1969 https://scholar.valpo.edu/gradcatalogs/1005/thumbnail ...
Valparaiso University
core +2 more sources