FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
BookTok Reading Practices : Intensive andExtensive Reading in Display Mode
The influence of BookTok on reading among young people has been highly debated in the lastfew years. The social media platform seems to have changed reading practices, the popularityof certain genres, and even the book and publishing industry.
Steiner, Ann
core
Differential profiles of reading development in neurodevelopmental disorders under an adapted tier 2 response to Intervention protocol. [PDF]
Front PediatrMousinho R +6 more
europepmc +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Extensive Reading Integrated with Intensive Reading
, 2017 ☞ 이 논문은 저자가 원문공개에 동의하지 않은 논문으로, 도서관 내에서만 열람이 가능하며, 인쇄 및 저장은 불가합니다.The purpose of this textbook is to help Christian students in Korea to read interesting stories in the Bible as they discover the joy of reading while at the same time developing their ...
황순주
core
Aging Is a Key Driver for Adult Acute Myeloid Leukemia
Aging and Cancer, EarlyView.Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley +1 more source
Intensive vs. extensive reading: a study on the impact of L2 reading interventions in 5th and 6th grade [PDF]
Extensive reading has proven to have various positive effects on students’ language competence in the L1. Therefore, L2 teachers are also encouraged to practice extensive reading with their students to develop their L2. Yet, studies focusing on extensive
Fried, Frauke
core
Preserve the distinction between passive and intensive skills training. [PDF]
Can Fam PhysicianDubord G.
europepmc +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Letter to the Editor Regarding: "OrthoKids and OrthoInfo Response to Training a Bilingual Artificial Intelligence Model on Pediatric Orthopaedic Resources to Enhance the Readability of Patient Education Materials". [PDF]
J Pediatr Soc North AmMurphy-Zane MS.
europepmc +1 more source