Results 131 to 140 of about 5,317,329 (303)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Lake Maurice, South Australia [cartographic material].
, 1942 1st ed. Relief shown by form lines and spot heights.; "This map is compiled from the latest Commonwealth and State information and is not the result of precise military survey"; "This map is an official document.
Australia. Army. Survey Corps.
core
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Oodnadatta, South Australia [cartographic material].
, 1941 1st ed. Shows telephone and power lines, electric power stations, roads, railways and aerodromes.; Relief shown by hachures and spot heights.; "This map is compiled from the latest Commonwealth and State information and is not the result of precise ...
Australia. Army. Survey Corps.
core
Rational use of intensive care beds in Turkey: Point prevalence survey study
Objective: The limitation or withdrawal of futile treatment is widely accepted in the intensive care and medical ethics literature. However, implementing this in clinical practice is often difficult. The aim of the study is to understand the situation of
Demirag, Kubilay +6 more
core +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Ireland 1:250,000 series : [cartographic material] Ordnance Survey holiday map /
, 1980 Various eds. Tourist map series of Ireland showing international and county boundaries, roads, railways, water features, buildings and populated places.
Ordnance Survey (Ireland).
core
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Innamincka, South Australia [cartographic material].
, 1942 1st ed. Shows telephone and power lines, electric power stations, roads, railways and aerodromes.; Relief shown by land forms, form lines and spot heights.; "This map is compiled from the latest Commonwealth and State information and is not the result of
Australia. Army. Survey Corps.
core
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source