Results 141 to 150 of about 236,914 (218)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pediatric Intensive Care Core Outcomes-a modified Delphi consensus process (PIC-CO). [PDF]

Crit Care
Mand N, Lieftüchter V, Westhoff JH, Hort S, Biedermann R, Müller-Brandes C, Merker M, Fuchs H, Cardona F, Beer A, Hoffmann F, Regner F, Lampe S, Pönicke C, Härtel C, Brickmann C, Bruns N, Section of Pediatric Intensive Care and Emergency Medicine of the German Interdisciplinary Association of Intensive Care and Emergency Medicine (DIVI).   +17 more
europepmc   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Standard Intravenous Concentrations in German Neonatal Intensive Care: Results of a National Consensus and Cross-Sectional Survey. [PDF]

J Clin Med
Wende L, Kaune A, Schoberer M, Orlikowsky T, Wackernagel D, Haering-Zahn J, Schöne F, Bach D, Rösner B, Schubert S, Goelz R, Krämer I, Kreutzer KB, Eisert A.   +13 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

Intraoperative Hypotension and Vasoactive Treatment: An International Survey of Anaesthesiologists. [PDF]

Acta Anaesthesiol Scand
Bækgaard ES, Vester-Andersen M, Crone V, Møller MH, Yamanaka S, Palmarsdottir R, Uusalo P, Haidl F, Rådestad M, van der Sloot K, Corona A, Johnström A, Nørskov AK, Karlsen APH, Faustad BI, Sørensen CB, Spies F, Krogh HB, El-Hallak H, Mistry JM, Mønnich JK, Olesen KG, Madsen KPD, Voogd KL, Reich LM, Kolstrup LA, Juhl-Olsen P, Körner LK, Sigurdsson MI, Jensen-Holm MB, Slavensky JA, Toft MH, Jørgensen ML, Andersen M, Jensen MSH, Saei M, Hedetoft M, Hansen PM, Hansen RT, Lundsgaard RS, Krarup SMI, Wiberg S, Laustrup T, Brizzi G, Kreutziger J, Onyemuchara I, Adeniji A, Colville T, Keitley JA, Khan M, Millar M, Lennie I, Kelly K, Brooker V, Roberts J, Lipton G, Keohone J, Chebbout R, Bond O, Milligan W, O'Brien C, Wright E, Linton F, Towell C, Shuttleworth J, Norton J, Butler D, Frankland S, Screech F, Charig L, Walsh S, Davies R, Jones E, Dalmonte E, Evans M, Krag M.   +75 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Activities and Time Spent on Rehabilitation in Scandinavian ICUs: A Cross-Sectional Survey Among Healthcare Professionals. [PDF]

Acta Anaesthesiol Scand
Alfheim HB, Svenningsen H, Holm A, Ågård AS, Åkerman E, Lind R, Nielsen AH, Collet MO.   +7 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source