Results 161 to 170 of about 1,415,466 (305)

Clinical practice in using corticosteroids and adjunctive sepsis therapies at the bedside among European ICUs: an ESICM-endorsed survey. [PDF]

Intensive Care Med Exp
David S, Leone M, Girardis M, Müller MM, Gavrilovic S, Domizi R, Damiani E, Martin-Loeches I, Ferrer R, Chousterman B, Russell L, ESICM “systemic inflammation, sepsis” (SIS) section.   +12 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Pregnancy and parenthood among Italian residents in anesthesia and intensive care - a national survey. [PDF]

J Anesth Analg Crit Care
Boscolo A, Battaglini D, Bove T, Cinella G, Discenza A, Piazza O, Rocco M, Scarpati G, Vaschetto R, Rubulotta F, Sella N, Navalesi P, INSPIRE (Italian National Survey On Parenthood During Intensive Care REsidency) group.   +12 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Pain Management in Aneurysmatic Subarachnoid Haemorrhage: A Survey of Nordic Physicians. [PDF]

Acta Anaesthesiol Scand
Sariola H, Kalliomäki ML, Kiiski H, Raatikainen E, Frösen J, Reinikainen M, Savioja H, Møller K, Lohela T, Takala R, Sigurdsson M, Romundstad L, Dyrskog S, Bülow K, Hästbacka J.   +14 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Physiotherapy in deceased organ donation: A mixed methods study of current practice and perceptions amongst UK-based intensive care physiotherapists. [PDF]

J Intensive Care Soc
Saunders S, Swingwood E, van Willigen Z, Rand S, Shannon H.   +4 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Pediatric Intensive Care Core Outcomes-a modified Delphi consensus process (PIC-CO). [PDF]

Crit Care
Mand N, Lieftüchter V, Westhoff JH, Hort S, Biedermann R, Müller-Brandes C, Merker M, Fuchs H, Cardona F, Beer A, Hoffmann F, Regner F, Lampe S, Pönicke C, Härtel C, Brickmann C, Bruns N, Section of Pediatric Intensive Care and Emergency Medicine of the German Interdisciplinary Association of Intensive Care and Emergency Medicine (DIVI).   +17 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source