Results 191 to 200 of about 186,818 (222)

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

The impact of family functioning on fertility intentions among university students: a study based on latent profile analysis. [PDF]

BMC Public Health
Peng H, Chou X, Zhang Z, Qiu H.
europepmc   +1 more source

Calcium Channel Blockers Inhibit Pancreatic Neuroendocrine Neoplasms Progression via Cav1.2‐Epigenetic Circuit

Advanced Science, EarlyView.
Our study reveals a novel mechanism of a positive regulatory circuit between Cav1.2 and H3K27ac for pancreatic neuroendocrine neoplasms (pNENs) progression. Cav1.2 is identified as a crucial target for promoting disease progression and correlates with malignant behaviors, which are remarkably inhibited by the administration of calcium channel blockers (
Yangyinhui Yu, Qiongcong Xu, Jinzhao Xie, Mingjian Ma, Xitai Huang, Yinhao Shi, Jiawei Zhou, Enliang Zhu, Ziyi Zhao, Ning Zhang, Zhide Liu, Jingyuan Ye, Xiaoyu Yin   +12 more
wiley   +1 more source

Intention to Leave the Profession in Nursing: A Hybrid Concept Analysis. [PDF]

J Caring Sci
Dabaghi S, Nabizadeh-Gharghozar Z, Amanibani A.   +2 more
europepmc   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Predictors of exclusive breastfeeding: a systematic review and meta-analysis. [PDF]

Int Breastfeed J
Kalhor M, Yazdkhasti M, Simbar M, Hajian S, Kiani Z, Khorsandi B, Sattari M, Ezadi Z, Nazem H, Jafari M.   +9 more
europepmc   +1 more source

Membrane‐Mediated Force Transduction Drives Stick‐Slip Motion of Lipid Vesicles

Advanced Science, EarlyView.
A rotating magnetic field actuates a ferromagnetic particle inside a lipid vesicle, generating internal flows that induce stick‐slip propulsion near a surface. Membrane properties—elasticity, excess area, and phase behavior—modulate this motion by shaping stress dissipation and force transduction.
Paula Magrinya, Arin Escobar Ortiz, Juan L. Aragones, Laura R. Arriaga   +3 more
wiley   +1 more source

Organizational Wellbeing and Quality of Life in Healthcare Settings: Unexpected Similarities Across Different Roles? [PDF]

Medicina (Kaunas)
Corallo F, Pagano M, Anselmo A, Cappadona I, Cardile D, Bonanno L, D'Aleo G, Migliara M, Libro S, Anchesi SD, De Luca R, Libro F, Longo Minnolo A, Crupi MF.   +13 more
europepmc   +1 more source

The effects of organization and community embeddedness on public health professionals' intention to stay during the COVID-19 pandemic: a cross-sectional study. [PDF]

Hum Resour Health
Wang H, Xu X, Yang Y, Li L.
europepmc   +1 more source

Effectiveness of organization-directed interventions on healthcare professionals' well-being: a systematic review. [PDF]

EClinicalMedicine
Boskma A, van der Braak K, Hooft L, Oerbekke M, Franx A, van der Laan M.   +5 more
europepmc   +1 more source