Results 51 to 60 of about 178,540 (295)

From ends to causes (and back again) by metaphor: the paradox of natural selection [PDF]

open access: yes, 2013
Natural selection is one of the most famous metaphors in the history of science. Charles Darwin used the metaphor and the underlying analogy to frame his ideas about evolution and its main driving mechanism into a full-fledged theory.
Blancke, Stefaan   +4 more
core   +1 more source

Personalized Selumetinib Dosing in Pediatric Neurofibromatosis Type 1: Insights From a Pilot Therapeutic Drug Monitoring Study

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate selumetinib exposure using therapeutic drug monitoring (TDM) in pediatric patients with neurofibromatosis type 1 (NF1) and plexiform neurofibromas (PN), assess interpatient pharmacokinetic variability, and explore the relationship between drug exposure, clinical response, and adverse effects.
Janka Kovács   +8 more
wiley   +1 more source

The Consequences of Anthropomorphic and Teleological Beliefs in a Global Pandemic

open access: yesBehavioral Sciences
To describe something in terms of its purpose or function is to describe its teleology. Previous studies have found that teleological beliefs are positively related to anthropomorphism, and that anthropomorphism decreases the perceived unpredictability ...
Andrew J. Roberts   +2 more
doaj   +1 more source

Orangutans modify facial displays depending on recipient attention [PDF]

open access: yesPeerJ, 2015
Primate facial expressions are widely accepted as underpinned by reflexive emotional processes and not under voluntary control. In contrast, other modes of primate communication, especially gestures, are widely accepted as underpinned by intentional ...
Bridget M. Waller   +2 more
doaj   +2 more sources

Phenomenological Actualism. A Husserlian Metaphysics of Modality? [PDF]

open access: yes, 2014
Considering the importance of possible-world semantics for modal logic and for current debates in the philosophy of modality, a phenomenologist may want to ask whether it makes sense to speak of “possible worlds” in phenomenology.
Wallner, Michael
core  

Adherence to Protocol Recommendations for Children With Wilms Tumour in Two Consecutive Studies in the United Kingdom and Ireland—Does Variation Matter?

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background and Aims Wilms tumour (WT) has excellent event‐free and overall survival (OS). However, small differences exist between countries participating in the same international study. This led us to examine variation in adherence to protocol recommendations as a potential contributing factor.
Suzanne Tugnait   +23 more
wiley   +1 more source

Triangle(s) of Being: Linguistic (Coserian) and Semiotic (Peircean) Perspectives

open access: yesAmerican, British and Canadian Studies Journal, 2023
This article envisages a possible tripartite division of (types of) being, in correspondence, one the one hand, to Eugenio Coseriu’s linguistic contents (significatum, designatum, sense) and on the other hand to Charles Sanders Peirce’s ‘participants’ in
Vîlcu Dumitru-Cornel
doaj   +1 more source

Linguistic Criteria of Intentionality [PDF]

open access: yes, 2016
The aim of this paper is to discuss theories that attempt to single out the class of intentional states by appealing to factors that are supposedly criterial for intentional sentences.
Tadeusz, Ciecierski
core   +2 more sources

Evaluating the Utility of Paired Tumor and Germline Targeted DNA Sequencing for Pediatric Oncology Patients: A Single Institution Report

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski   +9 more
wiley   +1 more source

Intravitreal GD2‐Specific Chimeric Antigen Receptor T‐Cell Therapy for Refractory Retinoblastoma

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Effective treatments for advanced, treatment‐resistant retinoblastoma (RB) remain limited. GD2‐specific chimeric antigen receptor (CAR) T cells show potent antitumor activity with minimal toxicity but have not previously been evaluated in RB.
Subongkoch Subhadhirasakul   +13 more
wiley   +1 more source

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