Results 71 to 80 of about 265,449 (188)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Memory and the Intentional Stance

open access: yes, 2018
Despite Dennett’s vast scholarship, he seemed to only have directly addressed the topic of memory in a relatively unknown coauthored article published in a somewhat obscure volume.
Felipe De Brigard
core   +1 more source

Teleological markers: Seven lines of hypotheses around Dennett's theory of habits

open access: yesScientia et Fides, 2014
Neuroscientists frequently use two folk psychology terms –self and consciousness– in formulating decision-making process models. According to Daniel Dennett, such notions lead them to dualistic view of brain functions and hence to dead ends or, at least,
Luis E. Echarte
doaj   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Disinformation as weaponised ignorance: A hybrid teleological–epistemic framework [PDF]

open access: yesCyberspace Studies
Background: Contemporary debates on disinformation are dominated by two influential approaches: Fallis’s functional (teleological) model and Simion’s purely epistemic Disinformation as Ignorance-Generating Content (DIGC) model. Their respective strengths
Ramin Rambod, Hadi Samadi, Shahla Eslami
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Belief in sharing the same phenomenological experience increases the likelihood of adopting the intentional stance towards a humanoid robot

open access: yes, 2022
Humans interpret and predict others’ behaviors by ascribing them intentions or beliefs, or in other words, by adopting the intentional stance. Since artificial agents are increasingly populating our daily environments, the question arises whether (and ...
Jairo Perez-Osorio   +3 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

The Default Mode of Human Brain Function Primes the Intentional Stance [PDF]

open access: yes, 2015
■ Humans readily adopt an intentional stance to other people, comprehending their behavior as guided by unobservable mental states such as belief, desire, and intention.
Spunt, Robert P   +8 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

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