Results 61 to 70 of about 255,850 (308)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Fuel Efficient High-Density Platooning Using Future Conditions Prediction

IEEE Open Journal of Intelligent Transportation Systems, 2022
A promising application of cooperative driving is high-density platooning, which main goal is to reduce fuel consumption by driving with inter-vehicle distances below ten meters.
Guillaume Jornod, Andreas Pfadler, Sofia Carreira, Ahmad El Assaad, Thomas Kurner   +4 more
doaj   +1 more source

Boxplot intra vs inter clusters correct-prediction.

, 2014
Boxplot intra vs inter clusters correct-prediction.
Mansoor Saqi (64402), Allan Tucker (6409), Artem Lysenko (430534), Stephen Swift (6408), Valeria Bo (626436), Tanya Curtis (626437)   +5 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

CopulaNet: Learning residue co-evolution directly from multiple sequence alignment for protein structure prediction

Nature Communications, 2021
Protein structure prediction is a challenge. A new deep learning framework, CopulaNet, is a major step forward toward end-to-end prediction of inter-residue distances and protein tertiary structures with improved accuracy and efficiency.
Fusong Ju, Jianwei Zhu, Bin Shao, Lupeng Kong, Tie-Yan Liu, Wei-Mou Zheng, Dongbo Bu   +6 more
doaj   +1 more source

Reliability and validity in comparative studies of software prediction models

, 2005
Empirical studies on software prediction models do not converge with respect to the question "which prediction model is best?" The reason for this lack of convergence is poorly understood.
I. Myrtveit, E. Stensrud, Myrtveit, I, Shepperd, MJ, Stensrud, E, M. Shepperd   +5 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Normalization of Pain-evoked Neural Responses Using Spontaneous EEG Improves the Performance of EEG-based Cross-individual Pain Prediction

Frontiers in Computational Neuroscience, 2016
An effective physiological pain assessment method that complements the gold standard of self-report is highly desired in pain clinical research and practice.
Yanru eBai, Gan eHuang, Yiheng eTu, Ao eTan, Yeung Sam eHung, Zhiguo eZhang, Zhiguo eZhang   +6 more
doaj   +1 more source

Tech Report: GIS [PDF]

GIS applications are extensive, spanning project management, agriculture, urban planning, and emergency response. In project monitoring, GIS enables effective resource prediction and allocation.
Inter-American Development Bank
core   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source