Results 61 to 70 of about 6,173,743 (316)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Identification of photocrosslinking peptide ligands by mRNA display

open access: yesCommunications Chemistry, 2023
Photoaffinity labelling is a promising method for studying protein-ligand interactions. However, obtaining a specific, efficient crosslinker can require significant optimisation.
Yuteng Wu   +5 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Microclimate and the spatio-temporal dynamics of natural production of two ectomycorrhizal fungi from the Guineo-Sudanian ecozone in Benin

open access: yesGlobal Ecology and Conservation
The study aims to determine the relation between the micro-climate and the natural production of Amanita subviscosa, and Lactifluus gymnocarpoides, in the Guinea-Sudanian ecozone.
Abdoul-Azize Boukary   +7 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

INTERACTING INTERSECTIONS [PDF]

open access: yesInternational Journal of Modern Physics A, 1998
Intersecting p-branes can be viewed as higher-dimensional interpretations of multicharge extremal p-branes, where some of the individual p-branes undergo diagonal dimensional oxidation, while the others oxidize vertically. Although the naive vertical oxidation of a single p-brane gives a continuum of p-branes, a more natural description arises if one ...
Lü, H., Pope, C. N.
openaire   +3 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

On Interaction Quality in Human-Robot Interaction

open access: yesProceedings of the 9th International Conference on Agents and Artificial Intelligence, 2017
In many complex robotics systems, interaction takes place in all directions between human, robot, and environment. Performance of such a system depends on this interaction, and a proper evaluation of a system must build on a proper modeling of interaction, a relevant set of performance metrics, and a methodology to combine metrics into a single ...
Suna Bensch   +2 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Feature interaction: a critical review and considered forecast [PDF]

open access: yes, 2003
The state of the art of the field of feature interactions in telecommunications services is reviewed, concentrating on three major research trends: software engineering approaches, formal methods, and on line techniques.
Magill, Evan   +17 more
core   +1 more source

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