Results 81 to 90 of about 7,366,686 (308)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Experimental validation of unsteady models for fluid structure interaction: Application to yacht sails and rigs [PDF]

open access: yes, 2012
• We present full scale measurements on a yacht sailing upwind in moderate head swell • We highlight the unsteadiness of the loads : peaks may be twice the mean value • The dynamic behavior differs from the steady state : hysteresis loop • Experimental ...
AUGIER, Benoit   +3 more
core   +1 more source

Touch, communication and affect: a systematic review on the use of touch in healthcare professions

open access: yesSystematic Reviews
Background The following systematic review explores the uses and understandings of physical, human-to-human touch engagements in healthcare professions.
Raffaele Andrea Buono   +2 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Commentary on 'Philosophy of Interaction' by Dag Svanaes.

open access: yes, 2011
What is Interaction or Interactivity? Most HCI and Interaction Design textbooks do not really define (beyond more then one sentence) one of the most often used terms in our vocabulary. What seems so straightforward turns elusive when we try to dig deeper.
Hornecker, Eva
core   +3 more sources

Anthropomorphic AI: a toolkit for authoring and interacting with intelligent virtual agents for extended reality

open access: yesFrontiers in Virtual Reality
Intelligent Virtual Agents (IVAs), which embody an artificial intelligence (AI) in a humanoid representation, have enormous potential for immersive extended reality (XR) environments to enable natural and engaging human-AI interactions.
Ke Li   +6 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Concept-Driven Interaction Design Research

open access: yes, 2010
In this article, we explore a concept-driven approach to interaction design research with a specific focus on theoretical advancements. We introduce this approach as a complementary approach to more traditional, and well-known, user-centered interaction ...
Mikael Wiberg   +3 more
core   +1 more source

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