Results 81 to 90 of about 12,116,341 (303)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Touch, communication and affect: a systematic review on the use of touch in healthcare professions

open access: yesSystematic Reviews
Background The following systematic review explores the uses and understandings of physical, human-to-human touch engagements in healthcare professions.
Raffaele Andrea Buono   +2 more
doaj   +1 more source

Reflection 6 [PDF]

open access: yes, 2010
The 2nd International Academic Forum forthe Next Generation, The 4th ICIS International Forum, The 3rd ICIS International Symposium, Korean Studies Advancement Center and ICIS CosponsoredInternational Symposium, Some Thoughts on Bōnotsu, Conversation of ...
Institute For Cultural Interaction Studies Kansai University
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Analysis framework for the interaction between lean construction and building information modelling [PDF]

open access: yes, 2009
Building with Building Information Modelling (BIM) changes design and production processes. But can BIM be used to support process changes designed according to lean production and lean construction principles? To begin to answer this question we provide
Dave, B, Koskela, LJ, Owen, RL, Sacks, R
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Anthropomorphic AI: a toolkit for authoring and interacting with intelligent virtual agents for extended reality

open access: yesFrontiers in Virtual Reality
Intelligent Virtual Agents (IVAs), which embody an artificial intelligence (AI) in a humanoid representation, have enormous potential for immersive extended reality (XR) environments to enable natural and engaging human-AI interactions.
Ke Li   +6 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

The interaction between humans and knowledge management systems : rethinking the future [PDF]

open access: yes, 2019
In this workshop position paper, we propose a study to understand the importance of knowledge management systems among academics in Saudi higher education institutions, admitting that knowledge workers and Knowledge Management Systems are valuable ...
Almujally, Nouf, Joy, Mike
core  

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