Results 101 to 110 of about 9,563,918 (311)

IMPLEMENTATION OF UNSUPERVISED LEARNING MODELS FOR ANALYZING THE STATE'S SECURITY LEVEL

Сучасні інформаційні системи
Objective. Enhancing the effectiveness of preliminary analysis of the state's security level through the implementation of clustering models. Methodology. The process of creating unsupervised learning models and their peculiarities in tasks of analyzing
Oleksandr Laktionov, Oleksandr Shefer , Iryna Laktionova, Vasyl Halai , Andrii Podorozhniak   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Complement Factor H: solution structures and interactions with ligands [PDF]

, 2009
Factor H (FH) is a plasma glycoprotein that plays a central role in regulating the alternative pathway of complement. It is composed of 20 short complement regulator (SCR) domains.
Okemefuna, A.I.
core  

Macrophages as a source of tumoricidal activity (tumor-necrotizing factor) [PDF]

, 1980
Macrophage-enriched peritoneal exudate cells from mice infected with Mycobacterium bovis BCG, macrophage-like tumor cells (PU 5-1.8), and peritoneal macrophages propagated in vitro with macrophage growth factor released tumoricidal activity into the ...
Mannel, D N, Moore, R. N., Männel, D. N., Mergenhagen, S E, Mergenhagen, S. E., Moore, R N   +5 more
core   +1 more source

FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction.

PLoS Pathogens, 2019
HIV-1 is dependent on the host cell for providing the metabolic resources for completion of its viral replication cycle. Thus, HIV-1 replicates efficiently only in activated CD4+ T cells.
Arthur Roux, Héloise Leroy, Bénédicte De Muylder, Lucie Bracq, Samia Oussous, Isabelle Dusanter-Fourt, Ghina Chougui, Rachida Tacine, Clotilde Randriamampita, Delphine Desjardins, Roger Le Grand, Frederic Bouillaud, Serge Benichou, Florence Margottin-Goguet, Remi Cheynier, Georges Bismuth, Marianne Mangeney   +16 more
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Development and Testing of a Multimodal Acquisition Platform for Human-Robot Interaction Affective Studies

, 2014
Human-Robot Interaction (HRI) studies have recently received increasing attention in various fields, from academic communities to engineering firms and the media. Many researchers have been focusing on the development of tools to evaluate the performance
LAZZERI, NICOLE, DE ROSSI, DANILO EMILIO, MAZZEI, DANIELE   +2 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Exploring multimodal robotic interaction through storytelling for aphasics

, 2008
In this poster, we propose the design of a multimodal robotic interaction mechanism that is intended to be used by Aphasics for storytelling. Through limited physical interaction, mild to moderate aphasic people can interact with a robot that may help ...
Al Mahmud, Abdullah, Al Mahmud, A., Abdullah Al Mahmud, Mubin, O., Mubin, Omar (R17188), Omar Mubin   +5 more
core   +1 more source

A cytosolic factor mediating membrane recruitment of AP-1 clathrin adaptors [PDF]

, 2008
Transport of cargo within the endocytic and secretory pathway is generally mediated by coated vesicles. These vesicles are formed through the recruitment of cytosolic coat proteins to the donor membrane that act as a scaffold to form coated buds and ...
Suri, Gregor
core   +1 more source