Complement Factor H: solution structures and interactions with ligands
, 2009 Factor H (FH) is a plasma glycoprotein that plays a central role in regulating the alternative pathway of complement. It is composed of 20 short complement regulator (SCR) domains.
Okemefuna, A.I.
core
Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities [PDF]
, 2014 E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success.
Dias, David M +20 more
core +1 more source
FOXO1 transcription factor plays a key role in T cell-HIV-1 interaction.
PLoS Pathogens, 2019 HIV-1 is dependent on the host cell for providing the metabolic resources for completion of its viral replication cycle. Thus, HIV-1 replicates efficiently only in activated CD4+ T cells.
Arthur Roux +16 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Application of nonlinear factor analysis to genotype-environment interaction [PDF]
, 1987 The intention of this paper is to show how the methods of nonlinear factor analysis as developed by McDonald (Br. J. Math. Stat. Psychol. 20:205-215, 1967) can be used to study genotype-environment interaction. The method is applied to the interaction of
Boomsma, D.I. +4 more
core +1 more source
MicroorganismsThe coordination between transcription and mRNA processing is essential for eukaryotic gene regulation, yet the structural basis of this coupling remains poorly understood in Entamoeba histolytica, the protozoan parasite responsible for amoebiasis.
Juan David Ospina-Villa +6 more
doaj +1 more source
Integrated water, nutrient, and mulch management enhances yield efficiency and quality in globe artichoke [PDF]
Scientia Agricola: The effect of two variables interacting on crops has been the focus of most agronomic research. This study looked into how three factors interact to affect artichokes.
Serhat Ayas
doaj +2 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
INTERCULTURAL COMPETENCE AS A FACTOR OF STUDENTS’ SUCCESSFUL INTERCULTURAL INTERACTION
Вестник Кемеровского государственного университета, 2013 The paper deals with the problem of exchange students’ intercultural interaction. Intercultural competence is considered as a factor of successful intercultural interaction and academic adaptation abroad.
L. A. Nikolaeva
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