Results 91 to 100 of about 16,557,675 (399)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Two Functionally Deviating Type 6 Secretion Systems Occur in the Nitrogen-Fixing Endophyte Azoarcus olearius BH72

Frontiers in Microbiology, 2019
Type VI protein secretion systems (T6SSs) have been identified in many plant-associated bacteria. However, despite the fact that effector proteins may modulate host responses or interbacterial competition, only a few have been functionally dissected in ...
Xun Jiang, Andreas Beust, Praveen K. Sappa, Uwe Völker, Theresa Dinse, Julia Herglotz, Barbara Reinhold-Hurek   +6 more
doaj   +1 more source

Perturbative Gadgets at Arbitrary Orders

, 2008
Adiabatic quantum algorithms are often most easily formulated using many-body interactions. However, experimentally available interactions are generally two-body. In 2004, Kempe, Kitaev, and Regev introduced perturbative gadgets, by which arbitrary three-
A. Messiah, Edward Farhi, Stephen P. Jordan, T. Kato   +3 more
core   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Potentially harmful drug–drug interactions in the therapeutic regimens of persons with spinal cord injury [PDF]

, 2023
Shikha Gupta, Alaina Dhawan, Jillian Dhawan, Mary Ann McColl, Karen Smith, Alexander McColl   +5 more
openalex   +1 more source

TRRUST v2: an expanded reference database of human and mouse transcriptional regulatory interactions

Nucleic Acids Res., 2017
Transcription factors (TFs) are major trans-acting factors in transcriptional regulation. Therefore, elucidating TF–target interactions is a key step toward understanding the regulatory circuitry underlying complex traits such as human diseases.
Heonjong Han, Jae-Won Cho, Sang-Young Lee, Ayoung Yun, Hyojin Kim, D. Bae, Sunmo Yang, Chan Yeong Kim, Muyoung Lee, Eunbeen Kim, Sungho Lee, Byunghee Kang, Dabin Jeong, Yaeji Kim, Hyeon-Nae Jeon, Ha-eun Jung, S. Nam, Michael Chung, Jong-Hoon Kim, Insuk Lee   +19 more
semanticscholar   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like properties

Nature Communications
In March 2024, clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses were first detected in U.S. dairy cattle. Similar viruses have since caused 70 zoonotic human infections.
Thomas P. Fabrizio, Ahmed Kandeil, Walter N. Harrington, Jeremy C. Jones, Trushar Jeevan, Konstantin Andreev, Patrick Seiler, Jonathan Fogo, Morgan L. Davis, Jeri Carol Crumpton, John Franks, Jennifer DeBeauchamp, Peter Vogel, C. Scanlon Daniels, Rebecca L. Poulson, Andrew S. Bowman, Elena A. Govorkova, Richard J. Webby   +17 more
doaj   +1 more source

Calcium regulates the mycophagous ability of Burkholderia gladioli strain NGJ1 in a type III secretion system-dependent manner

BMC Microbiology, 2020
Background A rice associated bacterium Burkholderia gladioli strain NGJ1 demonstrates mycophagy, a phenomenon wherein bacteria feed on fungi. Previously, we have reported that NGJ1 utilizes type III secretion system (T3SS) to deliver a prophage tail-like
Sunil Kumar Yadav, Joyati Das, Rahul Kumar, Gopaljee Jha   +3 more
doaj   +1 more source

STRING 8—a global view on proteins and their functional interactions in 630 organisms

Nucleic Acids Res., 2008
Functional partnerships between proteins are at the core of complex cellular phenotypes, and the networks formed by interacting proteins provide researchers with crucial scaffolds for modeling, data reduction and annotation.
L. Jensen, Michael Kuhn, M. Stark, Samuel Chaffron, C. Creevey, J. Muller, T. Doerks, P. Julien, Alexander C. J. Roth, M. Simonovic, P. Bork, C. V. Mering   +11 more
semanticscholar   +1 more source