Results 91 to 100 of about 10,494,319 (348)

A working model for cytoplasmic assembly of H/ACA snoRNPs

FEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Two Functionally Deviating Type 6 Secretion Systems Occur in the Nitrogen-Fixing Endophyte Azoarcus olearius BH72

Frontiers in Microbiology, 2019
Type VI protein secretion systems (T6SSs) have been identified in many plant-associated bacteria. However, despite the fact that effector proteins may modulate host responses or interbacterial competition, only a few have been functionally dissected in ...
Xun Jiang, Andreas Beust, Praveen K. Sappa, Uwe Völker, Theresa Dinse, Julia Herglotz, Barbara Reinhold-Hurek   +6 more
doaj   +1 more source

Neutrinophilic Non-Standard Interactions

, 2016
We construct UV-complete models for non-standard neutrino interactions mediated by a sub-GeV gauge boson Z' coupled to baryon number $B$ or $B-L$. A flavor-dependent Z' coupling to neutrinos is induced by mixing a U(1)'-charged Dirac fermion with the ...
Farzan, Yasaman, Heeck, Julian
core   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like properties

Nature Communications
In March 2024, clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses were first detected in U.S. dairy cattle. Similar viruses have since caused 70 zoonotic human infections.
Thomas P. Fabrizio, Ahmed Kandeil, Walter N. Harrington, Jeremy C. Jones, Trushar Jeevan, Konstantin Andreev, Patrick Seiler, Jonathan Fogo, Morgan L. Davis, Jeri Carol Crumpton, John Franks, Jennifer DeBeauchamp, Peter Vogel, C. Scanlon Daniels, Rebecca L. Poulson, Andrew S. Bowman, Elena A. Govorkova, Richard J. Webby   +17 more
doaj   +1 more source

Towards a refined classification of class I dithiol glutaredoxins from poplar: biochemical basis for the definition of two subclasses

Frontiers in Plant Science, 2013
Glutaredoxins (Grxs) are small oxidoreductases particularly specialized in the reduction of protein-glutathione adducts. Compared to other eukaryotic organisms, higher plants present an increased diversity of Grxs which are organized into four classes ...
Jérémy eCouturier, Jérémy eCouturier, Jean-Pierre eJacquot, Jean-Pierre eJacquot, Nicolas eRouhier, Nicolas eRouhier   +5 more
doaj   +1 more source

Interaction Proteomics

Bioscience Reports, 2005
The term proteome is traditionally associated with the identification of a large number of proteins within complex mixtures originating from a given organelle, cell or even organism. Current proteome investigations are basically focused on two major areas, expression proteomics and functional proteomics.
MONTI, MARIA, Orru S., Pagnozzi D., PUCCI, PIETRO   +3 more
openaire   +4 more sources

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Transfer studies of polystyrene nanoparticles in the ex vivo human placenta perfusion model: key sources of artifacts

Science and Technology of Advanced Materials, 2015
Nanotechnology is a rapidly expanding and highly promising new technology with many different fields of application. Consequently, the investigation of engineered nanoparticles in biological systems is steadily increasing.
Stefanie Grafmueller, Pius Manser, Liliane Diener, Lionel Maurizi, Pierre-André Diener, Heinrich Hofmann, Wolfram Jochum, Harald F. Krug, Tina Buerki-Thurnherr, Ursula von Mandach, Peter Wick   +10 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source