Results 81 to 90 of about 9,657,547 (300)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Novel tools for genomic modification and heterologous gene expression in the phylum Planctomycetota

Applied Microbiology and Biotechnology
Members of the phylum Planctomycetota possess a plethora of intriguing and hitherto underexplored features including an enlarged periplasmic space, asymmetric cell division (“budding”), and a mostly undiscovered small molecule portfolio. Due to the large
Tom Haufschild, Jonathan Hammer, Nico Rabold, Veronika Plut, Christian Jogler, Nicolai Kallscheuer   +5 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Three-nucleon interactions: dynamics

, 2008
A discussion is presented of the dynamics underlying three-body nuclear forces, with emphasis on changes which occurred over several decades.Comment: Talk given at the FM50 symposium, Tokyo, October ...
Benjamin F. Gibson, Hideyuki Sakai, Kimiko Sekiguchi, M. R. Robilotta   +3 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Genotype B3.13 influenza A(H5N1) viruses isolated from dairy cattle demonstrate high virulence in laboratory models, but retain avian virus-like properties

Nature Communications
In March 2024, clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses were first detected in U.S. dairy cattle. Similar viruses have since caused 70 zoonotic human infections.
Thomas P. Fabrizio, Ahmed Kandeil, Walter N. Harrington, Jeremy C. Jones, Trushar Jeevan, Konstantin Andreev, Patrick Seiler, Jonathan Fogo, Morgan L. Davis, Jeri Carol Crumpton, John Franks, Jennifer DeBeauchamp, Peter Vogel, C. Scanlon Daniels, Rebecca L. Poulson, Andrew S. Bowman, Elena A. Govorkova, Richard J. Webby   +17 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

A novel strain isolated from methane seeps in the Kattegat belongs to the planctomycetal species Novipirellula methanifontis sp. nov.

Scientific Reports
Here, we present the bacterial isolate SH528T, a planctomycetal strain from the collection of Heinz Schlesner (Kiel University), a pioneer in the research on budding bacteria. Genomic and physiological features of the novel strain are characterized along
Myriel Staack, Tom Haufschild, Jonathan Hammer, Nicolai Kallscheuer, Gaurav Kumar, Christian Jogler   +5 more
doaj   +1 more source

Flavor Changing Scalar Interactions

, 1993
The smallness of fermion masses and mixing angles has recently been been attributed to approximate global $U(1)$ symmetries, one for each fermion type.
A. Antaramian, H. Georgi, H. Georgi, J. Polchinski, J.F. Donoghue, L. Wolfenstein, Lawrence Hall, P. Drell, S. L. Glashow, Steven Weinberg, W.-S. Hou, Y. Nir   +11 more
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source