SPATIAL SUMMATION OF INHIBITORY INFLUENCES IN THE EYE OF LIMULUS, AND THE MUTUAL INTERACTION OF RECEPTOR UNITS [PDF]
H. K. Hartline, Floyd Ratliff
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Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova +26 more
wiley +1 more source
Comparing Bayesian estimation and structural-after-measurement approaches for structural equation models with latent interactions and complex data structures. [PDF]
Cox K, Kelcey B.
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LV.—The interaction of chlorine and hydrogen. The influence of mass [PDF]
David Leonard Chapman +1 more
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β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Computational evaluation of AKT2 mutations reveals R274H and R467W as potential drivers of protein instability and inhibitor resistance in cancer therapy. [PDF]
Runa SA, Tonmoy MIQ, Islam MA, Islam MA.
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Mechanical Properties of the Avena Coleoptile As Related to Auxin and to Ionic Interactions [PDF]
Takashi Tagawa, James Bonner
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Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
A Practical Covariance-Based Method for Efficient Detection of Protein-Protein Attractive and Repulsive Interactions in Molecular Dynamics Simulations. [PDF]
Golcuk M, Gur M.
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