Results 111 to 120 of about 305,447 (272)

Improving critical thinking ability in elementary schools with interactive e-modules

Online Journal of Communication and Media Technologies
This research project focuses on developing an interactive e-module specifically designed to improve critical thinking skills in elementary school students. To achieve this goal, we used a research and development approach based on the 4D model, involving 36 fourth-grade students at Pasirhuni State Elementary School, Indonesia as the research sample ...
Deden Dicky Dermawan, Wuri Wuryandani, Herwin Herwin, Fivia Eliza, Istikhoroh Nurzaman, Sendi Fauzi Giwangsa, Nano Nurdiansah, Radinal Fadli, Sasmita Sari, Miftahul Jannah, Munawarah Munawarah   +10 more
openaire   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Developing an Interactive E-Module Based on Flipbook for Solid Geometry

EduMatSains : Jurnal Pendidikan, Matematika dan Sains
This research aims to develop an interactive E-Module based on flipbook on solid geometry material that is valid and feasible. The research method used is Research and Development (R&D). The development research model used is the level 1 development research model from Sugiyono. The research location is at SMPN 50 East Jakarta.
Diva Nathania, Santri Chintia Purba, Jitu Halomoan Lumbantoruan   +2 more
openaire   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Development of Interactive E-Modules for Elementary Students: Enhancing Learning Outcomes

PrimaryEdu : Journal of Primary Education
This study aims to develop an interactive e-module that can improve elementary school students' learning outcomes and provide a more interesting learning experience. The method used is research and development (R&D) with the ADDIE model. Data collection was carried out through questionnaires, interviews, tests, and document recording, which were ...
Tri Rika Safitri, Febrina Dafit
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Effectiveness of Integrated Interactive Problem Based Learning E-Modules in Improving Critical Thinking Abilities

Jurnal Paedagogy
This study aims to analyze the improvement of students' critical thinking skills by using interactive modules integrated with problem-based learning on the excretory system material.
Afreni Hamidah, Hawalya Hawalya, M. Erick Sanjaya   +2 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Using the Big Ideas in Cosmology to Teach College Students

, 2013
Recent advances in our understanding of the Universe have revolutionized our view of its structure, composition and evolution. However, these new ideas have not necessarily been used to improve the teaching of introductory astronomy students.
Bailey, Janelle M., Coble, Kimberly, Cominsky, Lynn R., McLin, Kevin M., Metevier, Anne J.   +4 more
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