Results 81 to 90 of about 41,220 (263)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

The Use of Interactive E-Modules to Increase Students' Interest in Learning Entrepreneurship at SMK Telkom Pekanbaru

Jurnal PAJAR (Pendidikan dan Pengajaran)
The problem in this study is the low interest in student learning in entrepreneurship subjects. The problem that appears is the lack of student involvement and student interest in the learning process.
Kebetulan Loi, Suarman, Almasdi Syahza
doaj   +1 more source

Utilization of Android-Based Interactive E-Modules [PDF]

Proceedings of the Proceedings of the 2nd International Conference on Social Sciences and Interdisciplinary Studies (formerly ICCSSIS), ICCSIS 2019, 24-25 October 2019, Medan, North Sumatera, Indonesia, 2019
Ricu Sidiq, Najuah Najuah, Pristi Lukitoyo   +2 more
openaire   +1 more source

Development of an Interactive English E-Module for Engineering Students at Malikussaleh University

Edu Cendikia: Jurnal Ilmiah Kependidikan
This study aimed to develop an interactive English e-module for Information Systems Engineering students. Research and Development (R&D) approach with the ADDIE models was implemented in this study which comprised five primary stage, namely analysis, design, development, implementation, and evaluation.
Bungsu Keumala Sari, Fidyati Fidyati, Nurlaila Nurlaila, Azmi Basri, Rayhan Farkira   +4 more
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Development of Interactive Learning E-Modules in Geography Subjects in High School

Jurnal Penelitian Pendidikan IPA
This research aims to develop an interactive learning e-module in the Geography class XI phase F of high school and test the level of validity, practicality, and effectiveness of the developed product. This research uses a Research and Development (R&D) approach with the ADDIE development model which includes the stages of analysis, design ...
Suryani, Lilis, Bentri, Alwen, Zen, Zelhendri, Amsal, Mutiara Felicita, , Rayendra, Zahara, Leni   +5 more
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Interactive e-Module on Exponential Material to Support Computational Thinking

International Journal of Information and Education Technology
An important aspect of 21st-century education is student-oriented teaching targeted at essential training skills that should be possessed, such as Computational Thinking (CT). All individuals need CT due to being helpful in solving various problems associated with computer science and mathematics, as well as daily life.
openaire   +1 more source