Results 241 to 250 of about 70,986 (299)

Be AWARE: An Anti-bias Toolkit to Limit Bias in Narrative Evaluation of Medical Trainees. [PDF]

MedEdPORTAL
Sandgren K, Baranay M, Koestner B, Schmitz A.   +3 more
europepmc   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Remote Assessment of Ataxia Severity in SCA3 Across Multiple Centers and Time Points

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Spinocerebellar ataxia type 3 (SCA3) is a genetically defined ataxia. The Scale for Assessment and Rating of Ataxia (SARA) is a clinician‐reported outcome that measures ataxia severity at a single time point. In its standard application, SARA fails to capture short‐term fluctuations, limiting its sensitivity in trials.
Marcus Grobe‐Einsler, Vivian Maas, Arian Taheri Amin, Jennifer Faber, Tamara Schaprian, Katharina Hill, Matthis Synofzik, Lisa H. Graf, Heike Jacobi, Manuela Lima, Ana F. Ferreira, Bart P. van de Warrenburg, Ilse H. J. Willemse, Dagmar Timmann, Andreas Thieme, Paola Giunti, Hector Garcia‐Moreno, Magda M. Santana, Jeannette Hübener‐Schmid, Elin H. Davies, Thomas Klockgether   +20 more
wiley   +1 more source

A Natural Language Processing Framework for Structuring and Visualizing Clinical Trial Eligibility Criteria at Scale: Protocol for a Quantitative Study. [PDF]

JMIR Res Protoc
Xie J, Parikh J, Liu J, Pandya S, Gong G.   +4 more
europepmc   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Dopaminergic modulation of behavioral and electrocortical markers of interpersonal performance monitoring in Parkinson's Disease. [PDF]

Commun Biol
Era V, Pesci UG, Moreau Q, Pezzetta R, Zabberoni S, Peppe A, Costa A, Taglieri S, Candidi M, Aglioti SM.   +9 more
europepmc   +1 more source

A novel method for histopathological analysis of oral squamous cell carcinoma: a pilot study using three-dimensional imaging to enhance local control. [PDF]

Front Oncol
Michcik A, Pęksa R, Garbacewicz Ł, Polcyn A, Choma P, Wojciechowska B, Drogoszewska B.   +6 more
europepmc   +1 more source

Epithelial-Mesenchymal Transition Markers in Clear Cell Renal Cell Carcinoma: Expression Patterns and Prognostic Significance. [PDF]

J Pers Med
Smoljo L, Mateljak T, Racetin A, Todorović P, Komić J, Komić L, Đolonga P, Grubišić DA, Kostić S, Vukojević K, Kelam N.   +10 more
europepmc   +1 more source

A web-based prognostic nomogram incorporating VETC-associated imaging markers for predicting postoperative recurrence in hepatocellular carcinoma. [PDF]

BMC Cancer
Zhao YM, Xie SS, Yu YQ, Li ZX, Qin JM, Hu ZD, Zhang YM, Ye ZX, Yan JH, Shen W.   +9 more
europepmc   +1 more source