Results 111 to 120 of about 1,031,896 (310)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Personality Traits Bias the Perceived Quality of Sonic Environments
Applied Sciences, 2016 There have been few empirical investigations of how individual differences influence the perception of the sonic environment. The present study included the Big Five traits and noise sensitivity as personality factors in two listening experiments (n = 43,
PerMagnus Lindborg, Anders Friberg
doaj +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Unknown knowns; uncovering tacit knowledge for the design of interactive media [PDF]
, 2005 In my research I am exploring the potential role as a mediator between cultural heritage, as represented by traditional craftmakers, and people today who are interested in employing and understanding these skills.
Wood, N.
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Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Media Culture 2020: collaborative teaching and blended learning using social media and cloud-based technologies [PDF]
, 2015 The Media Culture 2020 project was considered to be a great success by all the partners, academics and especially the students who took part. It is a true example of an intercultural, multidisciplinary, blended learning experience in higher education ...
Field, James +2 more
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Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Live Blogging and Social Media Curation: Challenges and Opportunities for Journalism [PDF]
, 2013 Blogging and social media’s contribution to a realignment of the relationship between journalists and their audiences is discussed by Einar Thorsen in Live Blogging and Social Media Curation.
Thorsen, Einar
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Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
iScienceSummary: During performances, audiences experience various emotional states, and these are reflected in their ongoing facial expressions. We investigated if audience engagement could be determined by measuring the inter-subject correlation (ISC) of non ...
Richard A. Oakes +2 more
doaj +1 more source