Results 171 to 180 of about 63,382 (353)

Exploring the role of EBV in multiple sclerosis pathogenesis through EBV interactome

Frontiers in Immunology
BackgroundEpstein-Barr virus (EBV) is a known risk factor for multiple sclerosis (MS), even though the underlying molecular mechanisms are unclear and engage multiple immune pathways.
Chiara Ballerini, Roberta Amoriello, Olfa Maghrebi, Gianmarco Bellucci, Ilaria Addazio, Matteo Betti, Maria Grazia Aprea, Camilla Masciulli, Arianna Caporali, Valeria Penati, Clara Ballerini, Ermelinda De Meo, Emilio Portaccio, Marco Salvetti, Marco Salvetti, Maria Pia Amato, Maria Pia Amato   +16 more
doaj   +1 more source

A systems biology approach to prediction of oncogenes and molecular perturbation targets in B‐cell lymphomas

Molecular Systems Biology, 2008
The computational identification of oncogenic lesions is still a key open problem in cancer biology. Although several methods have been proposed, they fail to model how such events are mediated by the network of molecular interactions in the cell.
Kartik M Mani, Celine Lefebvre, Kai Wang, Wei Keat Lim, Katia Basso, Riccardo Dalla‐Favera, Andrea Califano   +6 more
doaj   +1 more source

Interactome network analysis (protein-protein).

, 2015
Interactome analysis of candidate proteins with current standard HCC biomarker AFP was retrieved by tools: GeneMANIA (A & B), STRING (C & D). Interacting partners of AFP (TP53, FOXA1, FOXA3, GPC3, IGFBP1, NR3C1, F2, AHSG, ACTL6A and JUN) along with DKK1 ...
Anam Naz (800890), Hussnain Ahmed Janjua (800893), Ayesha Obaid (800891), Jamil Ahmad (327791), Amjad Ali (51075), Faryal Mehwish Awan (800889), Sadia Anjum (800892)   +6 more
core   +1 more source

The global Microcystis interactome

, 2020
Bacteria play key roles in the function and diversity of aquatic systems, but aside from study of specific bloom systems, little is known about the diversity or biogeography of bacteria associated with harmful cyanobacterial blooms (cyanoHABs).
Jiang, H., Meyer, E.I., Hamilton, D.P., Cai, H., Padisák, J., Cook, K.V., Krumholz, L.R, Burford, M.A., Zhu, G., Wilson, A.E., Sukenik, A., Li, C., Latour, D., Paerl, H.W., Grossart, H.-P., Steffen, M.M., Hambright, K.D., Qin, B., Zamor, R.M.   +18 more
core   +1 more source

Tetrazine Ligation in Living Systems: Beyond Fast Kinetics to Effective Bioorthogonality

Chemistry – A European Journal, EarlyView.
Rapid reaction kinetics (k2) alone do not ensure successful tetrazine ligation in living systems. This review introduces ‘effective orthogonality’—focusing on chemical survival, availability, and encounter—as a practical framework. We highlight how bottlenecks shift from cellular sinks to in vivo delivery limits, offering design strategies for reliable
Junhyeong Yim, Junyoung Park, Youngjun Lee, Jongmin Park   +3 more
wiley   +1 more source

Human Melanoma Interactome Set (SKCM, T and B Lymphocyte)

, 2018
Human melanoma interactome set, including SKCM, T and B Lymphocyte ...
HONGXU DING (3744241)
core   +1 more source

In silico analysis of putative interactions identifies fibroblasts as hubs for cell–cell communication during early regeneration of the zebrafish heart

Developmental Dynamics, EarlyView.
Abstract Background The zebrafish heart regenerates upon injury. During injury response, fibroblasts and endothelial cells accumulate at the site of damage, and cardiomyocyte cell cycle reentry allows cardiac muscle regrowth. It is relevant to understand how the different cell types communicate with each other to coordinate regeneration.
João A. S. Carvalho, Prateek Arora, Ines J. Marques, María Galardi‐Castilla, Louk Timmer, Eva van Rooij, Nadia Mercader   +6 more
wiley   +1 more source

A comprehensive two-hybrid analysis to explore the yeast protein interactome

Proceedings of the National Academy of Sciences of the United States of America, 2001
Takashi Ito, Tomoko Chiba, Ritsuko Ozawa, Mikio Yoshida, Masahira Hattori, Y. Sakaki   +5 more
semanticscholar   +1 more source

Compound heterozygous SLC12A5 variants expand the molecular and functional spectrum of KCC2‐developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Overview of the multimodal experimental approach integrating clinical, genetic, in silico, and in vitro investigations. Clinical: Representative EEG recording setup and ictal traces from affected patients. Genetic: Pedigrees for Families A and B highlighting the inheritance of the four identified SLC12A5 variants (A1, A2, B1, B2).
Mira Hamze, Robyn Whitney, Dorothée Ville, Nathalie Villeneuve, Anna‐Maria Hartmann, Lisa Becker, Jens Hausmann, Jinwei Zhang, Cathy Brier, Lucie I. Pisella, Perrine Friedel, Audrey Labalme, Eudeline Alix, Nicolas Chatron, Damien Sanlaville, Sylvie Gory‐Fauré, Eric Denarier, Christophe Porcher, Gaetan Lesca, Igor Medina   +19 more
wiley   +1 more source

DYRK1A roles in human neural progenitors

Frontiers in Neuroscience
IntroductionMutations in dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) represent one of the most prevalent monogenic causes of neurodevelopmental disorders (NDDs), often associated with intellectual developmental disorder and ...
Jeremie Courraud, Jeremie Courraud, Jeremie Courraud, Jeremie Courraud, Angélique Quartier, Angélique Quartier, Angélique Quartier, Angélique Quartier, Nathalie Drouot, Nathalie Drouot, Nathalie Drouot, Nathalie Drouot, Irene Zapata-Bodalo, Irene Zapata-Bodalo, Irene Zapata-Bodalo, Irene Zapata-Bodalo, Johan Gilet, Johan Gilet, Johan Gilet, Johan Gilet, Alexandra Benchoua, Jean-Louis Mandel, Jean-Louis Mandel, Jean-Louis Mandel, Jean-Louis Mandel, Amélie Piton, Amélie Piton, Amélie Piton, Amélie Piton, Amélie Piton, Amélie Piton   +30 more
doaj   +1 more source