Results 171 to 180 of about 79,704 (286)

Coordinated regulation of PIEZO2 by alternative splicing, post‐translational modification, membrane trafficking and protein partners

The Journal of Physiology, EarlyView.
Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise, Qinglu Li, Mary G. Garry   +2 more
wiley   +1 more source

RIPK3 Inhibition Mitigates Denervated Muscle Atrophy via NOX4‐Mediated Mitochondrial Restoration and Inflammation Suppression

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Peripheral nerve injury‐induced muscle atrophy shares core pathophysiological features with systemic wasting disorders including cachexia and sarcopenia, yet early molecular triggers remain undefined. This study investigates the pathogenic role of receptor‐interacting protein kinase 3 (RIPK3) in denervation atrophy.
Yuntian Shen, Chen Zhang, Zihao Zhao, Jia Yi, Xinlei Yao, Bingqian Chen, Hualin Sun   +6 more
wiley   +1 more source

Multiscale Interactome-Guided Prioritization of Candidate Herbs and Active Compounds for Hepatic Cirrhosis Using a Biased Random Walk Algorithm. [PDF]

Curr Issues Mol Biol
Lee JH, Bak SB, Lee WY, Kim YK.
europepmc   +1 more source

The Recycling Endosomal (Na+, K+)/H+ Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin‐Dependent Kinase 5 to the Plasma Membrane

Acta Physiologica, Volume 242, Issue 6, June 2026.
ABSTRACT Aim The alkali cation/proton exchanger NHE6/SLC9A6 regulates luminal pH homeostasis and trafficking of recycling endosomes in most tissues, especially neurons. Loss‐of‐function mutations in NHE6 cause Christianson Syndrome, an X‐linked neurodevelopmental and neurodegenerative disorder; however, the underlying molecular and cellular mechanisms ...
Rebecca Flessner, Alina Ilie, Léo Han, Annie Boucher, Rebecca Anne McKinney, Reza Sharif‐Naeini, John Orlowski   +6 more
wiley   +1 more source

PrePPI - Structure-based Prediction of Protein-protein Interactomes and Networks. [PDF]

J Mol Biol
Velez C, Naravane A, Robila VI, Saha A, Murray D, Honig B.   +5 more
europepmc   +1 more source

Constitutive and inducible oleoresin defenses share genetic architectures and mechanisms in Pinus taeda

New Phytologist, Volume 250, Issue 5, Page 2966-2987, June 2026.
Summary The oleoresin defense system of loblolly pine (Pinus taeda) protects trees from insects and pathogens and is an important source of renewable biofuels and chemicals, but the genetic basis of oleoresin production is poorly understood. We characterized the genetic architecture of oleoresin flow, resin canal number, stem wood terpene content, and ...
Mallory M. Morgan, Jared Westbrook, Christopher Dervinis, Tania Quesada, Salvador Gezan, Robert Sykes, Timothy S. Johnson, Gabriela Madrid, Matthew Lane, Alice Townsend, Thomas A. Colquhoun, John M. Davis, Daniel Jacobson, Gary F. Peter   +13 more
wiley   +1 more source

Beyond the Very Important Pharmacogenes (VIPs): Uncovering Shadow Pharmacogenes in the Human Drug Response Network. [PDF]

ACS Omega
de Melo NC, Accioli GS, Sánchez-Luquez K, Gomes MFF, Felicio AC, de Carvalho LM.   +5 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, Volume 16, Issue 5, Page 837-856, May 2026.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Interactome Analysis of the CC2D1A Scaffold Reveals Novel Neuronal Interactions and a Postsynaptic Role. [PDF]

Mol Cell Proteomics
Heller AT, Bhattacharya A, Li H, Turkalj L, Thiyagarajan S, Suzuki E, Mossa A, Zheng H, Hao L, Manzini MC.   +9 more
europepmc   +1 more source

COL12A1 rs970547 Polymorphism Predisposes Anterior Cruciate Ligament Injury by Inducing ER Stress and Impairing Fibroblast Function

Advanced Biology, Volume 10, Issue 5, May 2026.
The COL12A1 rs970547(A/A) polymorphism is over‐represented in Chinese male anterior cruciate ligament (ACL) injury patients. This variant destabilizes COL12A1 protein without altering transcript levels, driving compensatory upregulation of other collagen genes and inducing endoplasmic reticulum stress in ACL‐derived fibroblasts.
Wenchuan Zhao, Hong Chen, Junwei Wang, Yixin Li, Rui Chen, Jingyi Zhou   +5 more
wiley   +1 more source