Results 191 to 200 of about 63,382 (353)

Exploring the potential relevance of microRNAs targeting the ARVC-related gene interaction network to cancer: an in silico testing hypothesis

open access: yesJournal of Biological Research - Thessaloniki
Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) is a genetic disorder of the myocardium. Mutations in the PKP2, DSP, DSG2, DSC2, JUP, TMEM43, PLN and DES genes which encode proteins of the cardiac desmosome have been linked to the disease yet, the
Athanasios Balaskas   +5 more
doaj   +1 more source

Social Interactome Recommender Project

open access: yes, 2016
Contains a Word document and PDF of the final report, and the Powerpoint and PDF for our final presentation.Our team is working with the Social Interactome team to assist in coding the recommender functionality for the Social Interactome network. That is
Gray, Colin   +2 more
core  

GWAS genes +1 interactome.

open access: yes, 2014
The +1 interaction network for the 52 GWAS genes with intermediate and high significance ...
David B. Sattelle (347392)   +8 more
core   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

open access: yesInterdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu   +13 more
wiley   +1 more source

Predicting Oxidative Stress Interactome of Sperm

open access: yes, 2014
First interactome study of sperm.
Burak Ozkosem (441153)
core   +1 more source

Multi‐omics biomarkers for intestinal infection and inflammation in inflammatory bowel disease: Current evidence, translational challenges, and diagnostic opportunities

open access: yesInterdisciplinary Medicine, EarlyView.
Prospective multi‐site cohorts, multi‐omics profiling, and computational analysis may help identify biomarker patterns across clinical settings in IBD and superimposed infections. With further mechanistic and clinical validation, these signals could support the development of practical multi‐analyte tools for more precise diagnosis and management ...
Ziyu Yang   +7 more
wiley   +1 more source

COL1A1+ Epithelial Cells Orchestrate VEGFA‐VEGFR Signaling in Endometritis Revealed by Single‐Cell Analysis

open access: yesJournal of Clinical Laboratory Analysis, EarlyView.
Single‐cell RNA‐seq of normal and endometritis endometrium shows reduced epithelial cells and fate divergence toward ferroptosis or ribosome/antigen‐presentation programs. COL1A1+ epithelial cells act as an AP‐1–driven hub that enhances VEGFA–VEGFR signaling and remodels the vascular microenvironment.
Chengzi Tian, Zaiyi Li
wiley   +1 more source

Human protein interactome induced by first quasi-biclique QB1.

open access: yes, 2014
The interactome consists of 120 human proteins and 509 interactions among them. The density of the interactome is nearly 0.07.
Ujjwal Maulik (169015)   +1 more
core   +1 more source

The Regulatory Role and Mechanism of Myoferlin in Mitophagy During Papillary Thyroid Carcinogenesis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Papillary thyroid carcinoma (PTC) is the most prevalent subtype of thyroid cancer; however, the regulatory mechanisms by which mitophagy influences its progression remain inadequately elucidated. This study sought to examine the role of myoferlin (MYOF) in mitophagy and its molecular basis during PTC development. Utilizing three paired PTC and
Wen‐Chao Lyu   +6 more
wiley   +1 more source

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