Results 181 to 190 of about 79,704 (286)

Correction: DYRK1A roles in human neural progenitors. [PDF]

Front Neurosci
Courraud J, Quartier A, Drouot N, Zapata-Bodalo I, Gilet J, Benchoua A, Mandel JL, Piton A.   +7 more
europepmc   +1 more source

PAF Triggered Pyroptotic NETosis Aggravates Myocardial Ischemia/Reperfusion Injury

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Platelet activating factor (PAF) secreted by cardiomyocytes during MI/R, drives NETs formation and subsequent NETosis. PAF/NETosis signaling activation is an initiative and causal factor in driving MI/R injury. This study identifies dapagliflozin as a potent NETosis inhibitor, and demonstrates that manipulating PAF‐NETosis signal by dapagliflozin or ...
Jiawei Wu, Shule Zhang, Ruofan Du, Lina Kang, Guodong Zhao, Xue Bao, Haochi Yang, Ziqing Xie, Tianyu He, Huiyong Sun, Haiping Hao, Lijuan Cao   +11 more
wiley   +1 more source

Proximity labeling unveils potential roles of the Miro2-CISD1 network in mitochondrial dynamics and neuronal differentiation. [PDF]

Commun Biol
Kang IK, Lee S, Moon TK, Han AR, Yu DB, Jung M, Kwak C, Seo JK, Rhee HW, Kim SW, Woo HN, Mun JY, Lee H.   +12 more
europepmc   +1 more source

Abi3S212F Alzheimer's disease variant alters plaque structure and disrupts microglia

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract BACKGROUND Genetic variants affecting microglial function can influence Alzheimer's disease (AD) risk, yet the underlying mechanisms remain unclear. The AD‐associated ABI3S209F (Abi3S212F in mouse) variant regulates cytoskeletal dynamics, but its in vivo impact on pathology is unknown. METHODS: An Abi3S212F mouse was developed and crossed with
Claire A. Butler, Min Sung Gee, Katie O'Gara, Giedre Milinkeviciute, Celia Da Cunha, Shimako Kawauchi, Yueh‐Hao Lu, Nellie Kwang, Kate I. Tsourmas, Christiana Prekopa, Zechuan Shi, Heidi Yahan Liang, Sherilyn D. Collins, Zachary A. Pashkutz, Jenna A. Sanchez, Kai‐Xuan Shi, Amber D. Walker, Shuling Wang, Maigan L. A. Wong, Karina Genaro, Jonathan Neumann, Angela Gomez‐Arboledas, Duc M. Duong, Nicholas T. Seyfried, Andrea J. Tenner, Frank M. LaFerla, Ali Mortazavi, Vivek Swarup, Grant R. MacGregor, Kim N. Green   +29 more
wiley   +1 more source

Proximity-Based Phospho-Interactome (Prob-PhI) Characterization Reveals Distinct Signaling Activities of MEK1 and MEK2. [PDF]

Anal Chem
Wang Y, Xiao P, Fan L, Pan Y, Ma H, Wang R, Xu C, Zhang L.   +7 more
europepmc   +1 more source

Novel Insights Into the Association Between Parkinson's Disease and Constipation: Role of SHMT2 as a Promising Biomarker

CNS Neuroscience &Therapeutics, Volume 32, Issue 5, May 2026.
This study integrated bioinformatics analysis, cellular models, and PD/constipation mouse models to identify SHMT2 as a key shared biomarker linking Parkinson's disease and constipation. SHMT2 upregulation was validated in dopaminergic neurons and the enteric nervous system, highlighting its potential role in gut–brain axis dysfunction.
Jiehua Su, Kaixun Huang, Xiuna Jing, Xiaohuan Liu, Cheng Wen, Rulin Geng, Zhuoying Lai, Zhijia Ruan, Yiqiang Zhan, Danyu Lin, Enxiang Tao   +10 more
wiley   +1 more source

SplitTurboID mapping of dimeric protein phosphatase complex interactomes. [PDF]

iScience
Rajkumar A, Gaudreau-Lapierre A, Anthony CLF, Nguyen V, Ooi S, Campuzano D, Trinkle-Mulcahy L.   +6 more
europepmc   +1 more source

Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons

European Journal of Pain, Volume 30, Issue 5, May 2026.
ABSTRACT Introduction Understanding the molecular architecture of peripheral sensory neurons is critical as we pursue novel drug targets against pain and neuropathy. Sensory neurons in the dorsal root ganglion (DRG) show extensive compartmentalization; thus, understanding each compartment—from the peripheral to central terminals—is key to this effort ...
Julia R. Sondermann, Allison M. Barry, Feng Xian, Thomas Haberl, David Gomez‐Varela, Fritz Benseler, Dietmar Schreiner, Nils Brose, Noa Lipstein, Manuela Schmidt   +9 more
wiley   +1 more source

On the Feasibility of Clinical Studies with Cross-Linking Mass Spectrometry. [PDF]

J Proteome Res
Park SG, Ostrom EL, Liu S, Marcinek DJ, Bruce JE.   +4 more
europepmc   +1 more source

When Viruses Talk through Extracellular Vesicles: a New Perspective on Sars‐Cov‐2‐Induced Neurodegeneration

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT SARS‐CoV‐2 infection is linked to persistent neurological symptoms Post‐Acute Sequelae SARS‐CoV‐2 (neuro‐PASC) and elevated risk of neurodegenerative disease, but molecular events connecting acute viral injury to long‐term CNS dysfunction remain unclear.
Gunjan Bawne, Loet Coenen, Erik Nutma, Jinte Middeldorp, Magdalena J. Lorenowicz   +4 more
wiley   +1 more source