Results 201 to 210 of about 79,704 (286)
Aging Cell, Volume 25, Issue 5, May 2026.Plasma dilution at 24 h after I/R improved cardiac remodeling, function, and the physical performance of old male and female mice, through lowered markers of inflammation, fibrosis, reduction of cardiomyocytes' apoptosis, increase in their cell‐cycle re‐entry, and healthier profile of newly synthesized proteome, including the determinants of Jak/Stat ...
Joana Marie C. Cruz +11 more
wiley +1 more source
Altered MDC1 Interactions and Dysfunctional DNA Repair in Lobular Breast Cancer Confers Sensitivity to PARP Inhibition. [PDF]
Cancer ResSottnik JL +15 more
europepmc +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
Structural variations in evolutionary novel genomic regions: new insights into neurodevelopmental disorders by long-read DNA Sequencing. [PDF]
Mol MedRincic M +7 more
europepmc +1 more source
Cancer Science, Volume 117, Issue 5, Page 1497-1509, May 2026.Proteomic mapping of Tax complexes in HTLV‐1–infected T‐cells identified IRF4 as a Tax interactor. Chromatin profiling showed Tax reprograms IRF4 occupancy with H3K27ac gains at super‐enhancers; Tax–IRF4 co‐expression altered chromatin accessibility and transcription, and ATL‐associated IRF4 mutants partially phenocopied these changes. ABSTRACT Human T‐
Shu Tosaka +4 more
wiley +1 more source
The Constrained Disorder Principle: A Paradigm Shift for Accurate Interactome Mapping and Information Analysis in Complex Biological Systems. [PDF]
Bioengineering (Basel)Ilan Y.
europepmc +1 more source
Cancer Science, Volume 117, Issue 5, Page 1362-1379, May 2026.Our findings identify circ‐0030167/IGF2BP1/HMOX1 axis as a critical regulatory factor targeting mitochondria‐mediated ferroptosis, thereby presenting a novel therapeutic target for PC combination therapies. ABSTRACT Pancreatic cancer (PC) represents a highly aggressive malignancy characterized by a 5 year survival rate of less than 12%.
Qun Zhao +6 more
wiley +1 more source
Selection for Molecularly Complementary Modules (MCMs) Drives the Origins and Evolution of Pleiofunctional, Epistatic Interactomes (PEIs). [PDF]
Life (Basel)Root-Bernstein R.
europepmc +1 more source
Why Is MS a More Frequent Complication of EBV Infection in Females?
Immunological Reviews, Volume 339, Issue 1, May 2026.ABSTRACT Multiple sclerosis (MS) is a T helper (Th) cell‐mediated disease that targets central nervous system (CNS) white matter. This disease affects three times more females than males. For many years, the etiology of MS was not well understood and the exact nature of the autoimmune reaction was speculative.
Shannon E. Dunn +2 more
wiley +1 more source