Results 221 to 230 of about 63,382 (353)

Functional characterization of 42 CK2α de novo variants associated with Okur‐Chung neurodevelopmental syndrome

The FEBS Journal, EarlyView.
Okur‐Chung neurodevelopmental syndrome (OCNDS) is a neurodevelopmental disorder associated with mutations in the gene coding for Protein kinase CK2α. In this work, 42 variants of CK2α associated with OCNDS were characterized in vitro. This included determination of catalytic activity and CK2α/CK2β‐interaction as well as an assessment of evolutionary ...
Alexander Gast, Christian Werner, Karsten Niefind, Joachim Jose   +3 more
wiley   +1 more source

Alphafuser: a parsimonious approach to predicting higher-order protein complexes. [PDF]

Acta Crystallogr D Struct Biol
Guillotin A, Hutin S, Masselot-Joubert L, Hammani K, Zubieta C, Nanao M.   +5 more
europepmc   +1 more source

Seventh Åland Island Meeting on von Willebrand Disease

Haemophilia, EarlyView.
ABSTRACT Introduction The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.
Riitta Lassila, Ruben Bierings, Nathan T. Connell, Fernando F. Corrales‐Medina, Augusto B. Federici, Veronica H. Flood, Floor Heubel‐Moenen, Jill M. Johnsen, Geoffrey Kuppens, Davide Matino, Carolyn Millar, Ingmar Schoen, Anish Sharda, Robert F. Sidonio Jr, Alok Srivastava, Timea Szanto, Angela C. Weyand, Erik Berntorp   +17 more
wiley   +1 more source

High-dimensional CRISPR-SERS interactomics tracks the topological evolution of plant viral pathogenesis and therapeutic response. [PDF]

Chem Sci
Dou Y, Wu G, Li J, Wang Y, Chen N, Xu T, Cai X, Zhang T, Zhang X, Li X, Li J, Sun Y.   +11 more
europepmc   +1 more source

Towards an integrated molecular understanding of plant hormones

Journal of Integrative Plant Biology, EarlyView.
This review offers a comprehensive overview of the nine plant hormones, delving into their biosynthesis, transport, signaling and crosstalk mechanisms. Because the complexity of plant hormonal control goes beyond these core elements, additional specific features are discussed. Lastly, this review highlights how fundamental insights drive hormonal‐based
Louise Vilain, Marie‐Laure Fauconnier, Manon Genva   +2 more
wiley   +1 more source

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases. [PDF]

Cell Genom
Cox RM, Papoulas O, Shril S, Lee C, Gardner TP, Ansari ZT, Battenhouse AM, Lee M, Drew K, McWhite CD, Yang D, Leggere JC, Durand D, Hildebrandt F, Wallingford JB, Marcotte EM.   +15 more
europepmc   +1 more source

MYB Factors: Hubs of Plant Stress and Hormone Crosstalk

Plant Biotechnology Journal, EarlyView.
ABSTRACT MYB transcription factors function as main regulatory hubs that integrate environmental signals with multi‐hormonal pathways to synchronize plant growth, metabolism and stress responses. This review delineates the regulatory roles of MYB in the signalling pathway of salicylic acid, jasmonic acid, ethylene and abscisic acid signalling.
Aye Aye Htun, Ya Wang, Jiahao Liu, Zhiqiang Guo, Yi Zheng, Wenjie Wang, Shuting Ma, Aolin Jia, Yan Ren, Feng Chen   +9 more
wiley   +1 more source

Mapping of the hSOX10 Proximal Protein Interactome in Human Melanoma. [PDF]

J Proteome Res
Newsom-Stewart CM, Bhatt DP, Major MB, Kaufman CK.   +3 more
europepmc   +1 more source

Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation

Plant, Cell &Environment, EarlyView.
ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner, Fruzsina Vadai‐Nagy, Magdolna Gombos, Attila Hlacs, Eszter Molnár, Annamária Marton, Csaba Vizler, Rasik Shiekh Bin Hamid, Péter Kaló, Attila Fehér, Zoltán Magyar   +10 more
wiley   +1 more source

Experimental assessment of AI-based interactome mapping. [PDF]

Nat Commun
Lambourne L, Yadav A, Wang Y, Desbuleux A, Kim DK, Laval F, Spirohn-Fitzgerald K, Cafarelli T, Pons C, Kovács IA, Jailkhani N, Schlabach S, De Ridder D, Luck K, Botchkarev VV, Debnath O, Bian W, Shen Y, Yang Z, Mee MW, Helmy M, Jacob Y, Lemmens I, Rolland T, McClain GG, Coté AG, Gebbia M, Kishore N, Knapp JJ, Mellor JC, Memisoglu G, Reimand J, Tavernier J, Cusick ME, Zhong Q, Aloy P, Hao T, Charloteaux B, Roth FP, De Las Rivas J, Falter-Braun P, Hill DE, Calderwood MA, Twizere JC, Vidal M.   +44 more
europepmc   +1 more source