Results 241 to 250 of about 53,983 (298)

High-dimensional CRISPR-SERS interactomics tracks the topological evolution of plant viral pathogenesis and therapeutic response. [PDF]

Chem Sci
Dou Y, Wu G, Li J, Wang Y, Chen N, Xu T, Cai X, Zhang T, Zhang X, Li X, Li J, Sun Y.   +11 more
europepmc   +1 more source

eEF1G Orchestrates Translation to Ensure Meiotic Progression in Transcriptionally Quiescent Spermatocytes

Advanced Science, Volume 13, Issue 52, 18 September 2026.
eEF1G supports translation elongation of meiotic mRNAs in transcriptionally quiescent leptotene and zygotene spermatocytes. Its depletion in germ cells causes meiotic arrest at the zygotene stage, with defective homologous synapsis and unstable recombination intermediates.
Jianze Xu, Yuwei Hu, Xukun Lu, Yuling Cai, Tongtong Li, Ming Gao, Jinlong Ma, Yuan Gao, Shangming Liu, Zi‐Jiang Chen, Jing Meng, Hongbin Liu, Xiaohua Jiang   +12 more
wiley   +1 more source

A protein interactome for the last eukaryotic common ancestor illuminates the biochemical basis of modern genetic diseases. [PDF]

Cell Genom
Cox RM, Papoulas O, Shril S, Lee C, Gardner TP, Ansari ZT, Battenhouse AM, Lee M, Drew K, McWhite CD, Yang D, Leggere JC, Durand D, Hildebrandt F, Wallingford JB, Marcotte EM.   +15 more
europepmc   +1 more source

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, Volume 13, Issue 53, 24 September 2026.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

Experimental assessment of AI-based interactome mapping. [PDF]

Nat Commun
Lambourne L, Yadav A, Wang Y, Desbuleux A, Kim DK, Laval F, Spirohn-Fitzgerald K, Cafarelli T, Pons C, Kovács IA, Jailkhani N, Schlabach S, De Ridder D, Luck K, Botchkarev VV, Debnath O, Bian W, Shen Y, Yang Z, Mee MW, Helmy M, Jacob Y, Lemmens I, Rolland T, McClain GG, Coté AG, Gebbia M, Kishore N, Knapp JJ, Mellor JC, Memisoglu G, Reimand J, Tavernier J, Cusick ME, Zhong Q, Aloy P, Hao T, Charloteaux B, Roth FP, De Las Rivas J, Falter-Braun P, Hill DE, Calderwood MA, Twizere JC, Vidal M.   +44 more
europepmc   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

Host interactomes of <i>Streptococcus oralis</i> and <i>Streptococcus gordonii</i> exposed to saliva or serum. [PDF]

Microbiol Spectr
Larsson A, Chao Y, Shannon O, Happonen L.   +3 more
europepmc   +1 more source

Network-driven discovery of repurposable drugs targeting hallmarks of aging. [PDF]

Nat Aging
Gross B, Ehlert J, Gladyshev VN, Loscalzo J, Barabási AL.   +4 more
europepmc   +1 more source

Kaiso Is a Novel TAZ-Interaction Partner That Promotes Hepatic Stellate Cell Activation and Regulates the Downstream lncRNA HIF1A-AS3. [PDF]

Int J Mol Sci
Abdelhamid AK, Pedrini F, Schmitt J, Fayed IH, Osama A, Rashwan HH, Hanna DMF, Menze ET, Magdeldin S, Luzarowski M, Sticht C, El-Demerdash E, Breuhahn K, Abdelaziz AI, El-Ekiaby N.   +14 more
europepmc   +1 more source