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Proximity Labeling of the Tau Repeat Domain Enriches RNA-Binding Proteins That Are Altered in Alzheimer's Disease and Related Tauopathies. [PDF]
Mol Cell ProteomicsShapley SM +11 more
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Acta Physiologica, 2006
AbstractThe many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one ...
J. Fürst +14 more
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AbstractThe many different functional phenotypes described in mammalian cells can only be explained by an intense interaction of the underlying proteins, substantiated by the fact that the number of independently expressed proteins in living cells seems not to exceed 25 K, a number way too small to explain the >250 K different phenotypes on a one ...
J. Fürst +14 more
openaire +3 more sources
Annual Review of Plant Biology, 2013
Protein-protein interactions are a critical element of biological systems, and the analysis of interaction partners can provide valuable hints about unknown functions of a protein. In recent years, several large-scale protein interaction studies have begun to unravel the complex networks through which plant proteins exert their functions.
Braun, Pascal +4 more
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Protein-protein interactions are a critical element of biological systems, and the analysis of interaction partners can provide valuable hints about unknown functions of a protein. In recent years, several large-scale protein interaction studies have begun to unravel the complex networks through which plant proteins exert their functions.
Braun, Pascal +4 more
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2021
The disease interactome is a network of genes that are related to each other through some attributes. These genes, being part of various diseases, show a high correlation among many diseases. Genes being a major part of the interactome thus can be used to determine the relationship between various diseases, their symptoms, clinical similarity, and co ...
Suma Dawn, Nidhi Jain, Tulika Gangwar
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The disease interactome is a network of genes that are related to each other through some attributes. These genes, being part of various diseases, show a high correlation among many diseases. Genes being a major part of the interactome thus can be used to determine the relationship between various diseases, their symptoms, clinical similarity, and co ...
Suma Dawn, Nidhi Jain, Tulika Gangwar
openaire +1 more source
ACS Chemical Biology, 2011
The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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Apoptosis, 2013
DAP-kinase (DAPK) is a Ca(2+)/calmodulin regulated Ser/Thr kinase that activates a diverse range of cellular activities. It is subject to multiple layers of regulation involving both intramolecular signaling, and interactions with additional proteins, including other kinases and phosphatases.
Shani, Bialik, Adi, Kimchi
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DAP-kinase (DAPK) is a Ca(2+)/calmodulin regulated Ser/Thr kinase that activates a diverse range of cellular activities. It is subject to multiple layers of regulation involving both intramolecular signaling, and interactions with additional proteins, including other kinases and phosphatases.
Shani, Bialik, Adi, Kimchi
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Biochemical Journal, 2012
The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation. In addition to its canonical function in chromosomal segregation, cohesin has been suggested by several lines of investigation in recent years to play additional roles in ...
Anil K, Panigrahi +3 more
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The cohesin complex holds the sister chromatids together from S-phase until the metaphase-to-anaphase transition, and ensures both their proper cohesion and timely separation. In addition to its canonical function in chromosomal segregation, cohesin has been suggested by several lines of investigation in recent years to play additional roles in ...
Anil K, Panigrahi +3 more
openaire +2 more sources
2004
Proteine liegen in Zellen als Multiproteinkomplexe vor, die entscheidend für die Funktionen von Proteinen und das Verhalten der Zellen sind. Wir haben eine Proteomics-Technologie entwickelt, mit der Proteinkomplexe in nativer Form analysiert werden können: die zweidimensionale Blau-Native-/SDS-Gelelektrophorese von Zelllysaten.
Schamel, W., Camacho-Carvajal, M.
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Proteine liegen in Zellen als Multiproteinkomplexe vor, die entscheidend für die Funktionen von Proteinen und das Verhalten der Zellen sind. Wir haben eine Proteomics-Technologie entwickelt, mit der Proteinkomplexe in nativer Form analysiert werden können: die zweidimensionale Blau-Native-/SDS-Gelelektrophorese von Zelllysaten.
Schamel, W., Camacho-Carvajal, M.
openaire +1 more source