Results 261 to 270 of about 53,983 (298)
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ACS Chemical Biology, 2011
The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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The mitogen-activated protein kinase (MAPK) signaling network is integrated into most, if not all, defined homeostatic and regulatory responses of eukaryotic cells. A systematic experimental and computational approach has been used to identify more than 2,000 protein interactions related to functions and regulation of the MAPK signaling network.
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Analyzing IDPs in Interactomes
2020Intrinsically disordered proteins (IDPs) and regions (IDRs) are commonly found in all proteomes analyzed so far. These proteins/regions are subject to numerous posttranslational modifications (PTMs) and alternative splicing, are involved in a wide range of cellular functions, and often facilitate protein-protein interactions (PPIs).
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Interactome of a Cardiopoietic Precursor
Journal of Cardiovascular Translational Research, 2008Pluripotency is a hallmark feature of embryonic stem cells, but concomitantly expressed transcripts confound resolution of specific developmental signaling axes. Ratification of a molecular fingerprint critical to cardiogenesis mandated investigation of gene expression in stem-cell-derived cardiac precursors undergoing guided differentiation to define ...
Randolph S, Faustino, Andre, Terzic
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2004
Proteine liegen in Zellen als Multiproteinkomplexe vor, die entscheidend für die Funktionen von Proteinen und das Verhalten der Zellen sind. Wir haben eine Proteomics-Technologie entwickelt, mit der Proteinkomplexe in nativer Form analysiert werden können: die zweidimensionale Blau-Native-/SDS-Gelelektrophorese von Zelllysaten.
Schamel, W., Camacho-Carvajal, M.
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Proteine liegen in Zellen als Multiproteinkomplexe vor, die entscheidend für die Funktionen von Proteinen und das Verhalten der Zellen sind. Wir haben eine Proteomics-Technologie entwickelt, mit der Proteinkomplexe in nativer Form analysiert werden können: die zweidimensionale Blau-Native-/SDS-Gelelektrophorese von Zelllysaten.
Schamel, W., Camacho-Carvajal, M.
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Deciphering the melanoma interactome
Journal of Cutaneous Pathology, 2008Late‐stage malignant melanoma continues to pose a significant therapeutic challenge, despite numerous recent advances in our understanding of the molecular and genetic pathways leading to tumor development and progression. Dr Scott McNutt was among the first researchers to employ the cutting edge technology, electron microscopy, to the study of ...
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Interactomes by mass spectrometry
Nature Methods, 2012Two different mass spectrometry–based approaches are applied to analyze protein complexes on a global scale.
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Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
Cell, 2022Danielle L Swaney +2 more
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The Interactome of the VAP Family of Proteins: An Overview
Cells, 2021Christina James, Ralph Kehlenbach
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Using Interactome Big Data to Crack Genetic Mysteries and Enhance Future Crop Breeding
Molecular Plant, 2021Hongwei Zhang, Lin Li, Guoying Wang
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