Results 271 to 280 of about 63,382 (353)

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, Volume 13, Issue 32, 9 June 2026.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Proximity-Based Phospho-Interactome (Prob-PhI) Characterization Reveals Distinct Signaling Activities of MEK1 and MEK2. [PDF]

Anal Chem
Wang Y, Xiao P, Fan L, Pan Y, Ma H, Wang R, Xu C, Zhang L.   +7 more
europepmc   +1 more source

Directed Evolution Improves the Catalytic Efficiency of APEX2‐Mediated Proximity‐Dependent RNA Labeling

Advanced Science, Volume 13, Issue 32, 9 June 2026.
ABSTRACT Engineered ascorbate peroxidase APEX2 has been widely used for spatially restricted profiling of subcellular biomolecules, but its catalytic efficiency toward newly developed probes such as biotin‐aniline (Btn‐An) remains suboptimal. To overcome this limitation, we performed yeast surface display‐based directed evolution to enhance APEX2 ...
Gang Wang, Yi Li, Peiyuan Meng, Peng Zou
wiley   +1 more source

SplitTurboID mapping of dimeric protein phosphatase complex interactomes. [PDF]

iScience
Rajkumar A, Gaudreau-Lapierre A, Anthony CLF, Nguyen V, Ooi S, Campuzano D, Trinkle-Mulcahy L.   +6 more
europepmc   +1 more source

Mapping cross‐domain drivers of Alzheimer's disease risk through integrated network analysis

Alzheimer's &Dementia, Volume 22, Issue 6, June 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) is a complex neurodegenerative disorder with numerous known risk factors. Identification of which genetic factors are causal drivers is difficult due to the long disease prodrome in an inaccessible organ.
Gregory A Cary, Stephen Keegan, Jesse C Wiley, Jake Gockley, Robert R Butler III, Frank M Longo, Allan I Levey, Anna K Greenwood, Karina Leal, Gregory W Carter, for The Emory‐Sage‐SGC‐JAX TREAT‐AD Center   +10 more
wiley   +1 more source

On the Feasibility of Clinical Studies with Cross-Linking Mass Spectrometry. [PDF]

J Proteome Res
Park SG, Ostrom EL, Liu S, Marcinek DJ, Bruce JE.   +4 more
europepmc   +1 more source

LncRNA MIR503HG serves as a diagnostic biomarker in patients with sepsis and regulates sepsis‐induced inflammation and cardiac dysfunction

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
MIR503HG was downregulated in sepsis and sepsis‐induced cardiac dysfunction (SICD) and served as a diagnostic biomarker. Overexpression of MIR503HG attenuated myocardial injury and systemic inflammation in a septic rat model. Mechanistically, MIR503HG acted as a ceRNA by sponging miR‐497‐5p to upregulate BDNF, revealing a protective MIR503HG/miR‐497‐5p/
Pingping Qi, Minghe Jiang, Minsheng Wu, Shengkui Chen, Qile Ye, Rong Tang   +5 more
wiley   +1 more source

Characterization of a Cytokine-Independent STAT5 Activator. [PDF]

Biomedicines
Aleck GA, Jin Y, Gu Z, Courtney AH.
europepmc   +1 more source

Exploring the Lung–Liver Axis in Pulmonary Arterial Hypertension

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
Among PAH patients without liver disease, subclinical liver dysfunction quantified by MELD‐Na associates with higher pulmonary vascular resistance and inflammatory activation of the pulmonary endothelium, characterized by an IL‐6‐centered transcriptional network enriched for leukocyte chemotaxis.
Navneet Singh, Jordan Lawson, Ashok Ragavendran, Somanshu Banerjee, Andy Hon, Alejandro Vega, Jason Hong, Christopher J. Mullin, Mandy Pereira, Allyson Sherman‐Roe, Alexander T. Jorrin, Tiffaney Cayton, Gregory Fishbein, James R. Klinger, William M. Oldham, Rui‐Sheng Wang, Zhiyu Dai, Michael Fallon, Elizabeth O. Harrington, Olin D. Liang, Soban Umar, Corey E. Ventetuolo   +21 more
wiley   +1 more source

TGF‐β1‐driven epithelial‒mesenchymal transition mediates the fibrotic process in IgG4‐related disease

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
In IgG4‐related disease, the epithelial‐to‐mesenchymal transition of fibroblasts was predominantly driven by transforming growth factor‐β1 secreted from CD19+ B cells. Reciprocally, fibroblasts facilitated CD19+ B‐cell survival and activation through CXCL14–CXCR4 and CXCL12–CXCR4 signalling axes, thereby promoting B‐cell responses and subsequent ...
In‐Woon Baek, Kyung‐Su Park, Ki‐Jo Kim   +2 more
wiley   +1 more source