Results 201 to 210 of about 10,129 (256)
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DNA intercalators as anticancer agents
Chemical Biology & Drug Design, 2022AbstractCancer is one of the most prevailing disease conditions, which occurs due to uncontrolled cell division either due to natural mutation to the genes or due to changes induced by physical, chemical, or biological carcinogens. According to WHO, it is the second leading cause of death worldwide and has reported 10 million deaths in 2020.
Sneha, Venugopal +4 more
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Polyfunctional DNA intercalating agents
Medicinal Research Reviews, 1986Laurence P G Wakelin
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Inhibition of hepatitis B DNA polymerase by intercalating agents
Nature, 1978INFECTION with hepatitis B virus (HBV) is widespread and increasing in incidence in many countries. Unfortunately, there is as yet no effective chemotherapy. The hepatitis B virion is unique in that it contains both circular DNA and a DNA polymerase enzyme (for review see ref. 1).
Shalom Z Hirschman +2 more
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Effects of intercalating agents on the structure of the ribosome
Biochemical and Biophysical Research Communications, 1975Summary Ribosomes treated with an intercalating dye (ethidium bromide or acridine orange) are degraded more rapidly by RNase I than untreated ribosomes. Spermidine or spermine counteracts to great extent the effect produced by the intercalating dye. It appears that the intercalation leads to the ‘loosening’ of the structure of the ribosome which is ...
T, Suryanarayana, D P, Burma
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Nilemycin, an intercalating agent for deoxyribonucleic acid
International Journal of Biochemistry, 19821. Nilemycin (NM) is found to exert an inhibitory effect on the mouse tumor Sarcoma 180 near toxic doses but not with Leukemia 1210. 2. In Yoshida rat sarcoma cells NM inhibits cellular de novo nucleic acid synthesis and protein to a much lesser extent. 3.
I R, Shimi +3 more
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Recent Advances in Copper Intercalators as Anticancer Agents
Journal of Fluorescence, 2018Copper is a part of various enzymes and helps them to function properly. It can be effectively used to produce promising anticancer drugs and presently, many studies are being pursued worldwide on the development of copper-based complexes as potential anticancer drugs.
C. Shobha Devi +3 more
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Mechanisms of Selectivity of Intercalating Agents
2015Intercalation, insertion of a conjugated polycyclic aromatic ligand between stacked bases of helical DNA, is a common means of binding for a number of agents. This mode of binding generally accounts directly for a number of effects which are broadly uniform for most cells under appropriate conditions.
H S, Schwartz +2 more
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On the fidelity of DNA synthesis: Effects of steroids and intercalating agents
Chemico-Biological Interactions, 1980Studies on the fidelity of DNA synthesis in vitro were extended to pharmacological agents that interact non-covalently to DNA. Several steroids, intercalators and cancer chemotherapeutic agents increased the relative frequency of incorrect deoxynucleotide incorporation in the fidelity assay.
M A, Sirover, L A, Loeb
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Chemico-Biological Interactions, 1985
We have used hydroxyapatite (HA) chromatography and S1 nuclease hydrolysis to study the modification in the secondary structure of DNA caused by certain intercalating and non-intercalating ligands. The principal conclusions of HA experiments were as follows: (1) when native DNA, complexed with drugs believed to bind to DNA by intercalation (ethidium ...
N K, Alvi, R Y, Rizvi, S M, Hadi
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We have used hydroxyapatite (HA) chromatography and S1 nuclease hydrolysis to study the modification in the secondary structure of DNA caused by certain intercalating and non-intercalating ligands. The principal conclusions of HA experiments were as follows: (1) when native DNA, complexed with drugs believed to bind to DNA by intercalation (ethidium ...
N K, Alvi, R Y, Rizvi, S M, Hadi
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Inhibition of the processing of ribosomal precursor RNA by intercalating agents
Journal of Molecular Biology, 1971Abstract Proflavin, ethidium, and ellipticine, compounds known or thought to bind to nucleic acid helices by intercalation, were found to inhibit the processing of 45 s nucleolar RNA to other RNA species in the ribosomal RNA maturation sequence in L1210 mouse lymphoma cells.
A L, Snyder, H E, Kann, K W, Kohn
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