Results 221 to 230 of about 10,129 (256)

Intercalation compounds of hydrotalcite-like anionic clays with antiinflammatory agents — I. Intercalation and in vitro release of ibuprofen

International Journal of Pharmaceutics, 2001
Hydrotalcite-like compounds are layered solids having positively charged layers and interlayer charge-compensating anions. The synthetic Mg0.67Al0.33(OH)2 Cl0.33.0.6H2O, which is biocompatible, has been used to intercalate a model drug, ibuprofen, in order to prepare a modified release formulation.
AMBROGI, Valeria, FARDELLA, Giuseppe, GRANDOLINI, Giuliano, PERIOLI, Luana   +3 more
openaire   +3 more sources

Intercalated samarium as an agent enabling the intercalation of oxygen under a monolayer graphene film on iridium

Technical Physics Letters, 2016
Using thermal desorption time-of-flight mass spectrometry and thermionic methods, it is shown that oxygen does not intercalate under a graphene monolayer grown correctly on iridium, at least at temperatures of T = 300–400 K and exposures below 12000 L.
E. Yu. Afanas’eva, E. V. Rut’kov, N. R. Gall’   +2 more
openaire   +1 more source

Control of gene expression by oligonucleotides covalently linked to intercalating agents

Genome, 1989
Oligodeoxynucleotides covalently linked to intercalating agents selectively recognize the complementary sequence of the oligonucleotide. The intercalating agent provides an additional binding energy which stabilizes the complex. These substances can be used in vitro to block mRNA translation.
C, Hélène, N T, Thuong
openaire   +2 more sources

Isoxazolidinyl polycyclic aromatic hydrocarbons as DNA-intercalating antitumor agents

European Journal of Medicinal Chemistry, 2011
The second generation and an isosteric series of isoxazolidinyl polycyclic aromatic hydrocarbons, as DNA-intercalator agents designed to act on remotely implanted tumors, have been synthesized in good yields according to the 1,3-dipolar cycloaddition methodology.
RESCIFINA, Antonio, CHIACCHIO, Ugo, CORSARO, Antonino, PIPERNO A, ROMEO R.   +4 more
openaire   +4 more sources

DNA Metalating–Intercalating Hybrid Agents for the Treatment of Chemoresistant Cancers

Chemistry – A European Journal, 2012
AbstractNonclassical platinum‐based antitumor agents have shown enormous potential in the treatment of chemoresistant cancers. The design of these agents is based on the hypothesis that platinum‐containing pharmacophores that react with nuclear DNA in cancer cells radically differently than the clinical agent cisplatin will produce a unique spectrum of
Jimmy, Suryadi, Ulrich, Bierbach
openaire   +2 more sources

Novel isoxazole polycyclic aromatic hydrocarbons as DNA-intercalating agents

European Journal of Medicinal Chemistry, 2012
The third generation of isoxazole polycyclic aromatic hydrocarbons, acting as DNA-intercalator agents and possessing the binding constants in the range 10(4)-10(5) M(-1), in order to easily diffuse targeting remotely implanted tumors, has been synthesized in good yields according to the 1,3-dipolar cycloaddition methodology.
RESCIFINA, Antonio, Varrica MG, Carnovale C, Romeo G, CHIACCHIO, Ugo   +4 more
openaire   +4 more sources

Oligonucleotides Attached To Intercalators, Photoreactive And Cleavage Agents

1991
Abstract During the past few years there has been a growing interest in the use of modified oligonucleotides as research tools in molecular biology and as specific inhibitors of gene expression. The potential therapeutic application of oligonucleotides as artificial gene control agents depends on the specificity of their binding to the ...
N T Thuong, U Asseline
openaire   +1 more source

Intercalating agents

Acta Crystallographica Section A Foundations of Crystallography, 1984
M. Hospital, J. P. Bideau, C. Courseille, J. Lhomme   +3 more
openaire   +1 more source

Mutagenicity of some intercalating agents in Chinese hamster V79 cells

Mutation Research/Genetic Toxicology, 1984
ICR 170 and ICR 191, but not 9-aminoacridine or chloroquine, induced both 6-thioguanine- and, to a smaller extent, ouabain-resistance in Chinese hamster V79 cells. These results indicate that covalent binding to DNA is necessary for intercalating agents to induce mutation in this cell line, and that this assay can distinguish potential carcinogens from
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DNA intercalating anti-tumour agents.

Anti-cancer drug design, 1991
Only a small proportion of DNA intercalators known today exhibit experimental anti-tumour activity and even fewer are useful clinically, raising the question of precisely what properties are necessary for an anti-cancer effect. A search for answers to this question has revealed a complex picture of how intercalators can interact with DNA and other ...
openaire   +1 more source