Results 141 to 150 of about 57,440 (259)

Salt bridges gate α-catenin activation at intercellular junctions. [PDF]

Mol Biol Cell, 2018
Barrick S, Li J, Kong X, Ray A, Tajkhorshid E, Leckband D.   +5 more
europepmc   +1 more source

Targeting a Myeloid–Regulatory B Cell Network Reverses Immune Paralysis in Periprosthetic Joint Infections

Advanced Science, EarlyView.
Periprosthetic joint infection establishes a sophisticated immunosuppressive network between CXCR4+ PMN‐MDSCs and Bregs, inducing profound CD8+ T cell paralysis. Alendronate effectively disrupts this CXCR4+ PMN‐MDSC–Breg axis by targeting STAT3, thereby restoring local immune surveillance.
Jintao Wu, Shutao Zhang, Yumin Lin, Juyang Jiao, Zhiwei Fu, Qimin Hong, Ziyi Zhao, Xinhua Qu, Fei Su, Bing Yue   +9 more
wiley   +1 more source

Vitamin D maintains E-cadherin intercellular junctions by downregulating MMP-9 production in human gingival keratinocytes treated by TNF-α. [PDF]

J Periodontal Implant Sci, 2019
Oh C, Kim HJ, Kim HM.
europepmc   +1 more source

Stiffness‐Activated Stellate Cells Drive Pancreatic Cancer Liver Colonization via GMFG‐TNS4 Signaling

Advanced Science, EarlyView.
Fibrotic liver stiffness activates hepatic stellate cells through Piezo1‐dependent calcium influx and ER stress, promoting EV‐associated GMFG release. Delivered GMFG engages TNS4 in pancreatic cancer cells, triggering FAK/AKT signaling, adhesion, and fatty acid synthesis.
Biwen Zhu, Jian Wan, Xue Zhang, Jiashuai Yan, Xi Chen, Xiaoqi Guan, Qianqian Ren, Tao Yang, Di Wu, Qingsong Guo, Yibing Guo, Yuhua Lu   +11 more
wiley   +1 more source

Cdc42 Deficiency Leads To Epidermal Barrier Dysfunction by Regulating Intercellular Junctions and Keratinization of Epidermal Cells during Mouse Skin Development. [PDF]

Theranostics, 2019
Zhang M, Wang X, Guo F, Jia Q, Liu N, Chen Y, Yan Y, Huang M, Tang H, Deng Y, Huang S, Zhou Z, Zhang L, Zhang L.   +13 more
europepmc   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Access to a main alphaherpesvirus receptor, located basolaterally in the respiratory epithelium, is masked by intercellular junctions. [PDF]

Sci Rep, 2017
Van Cleemput J, Poelaert KCK, Laval K, Maes R, Hussey GS, Van den Broeck W, Nauwynck HJ.   +6 more
europepmc   +1 more source

Membrane ultrastructure at mammalian intercellular junctions

Progress in Biophysics and Molecular Biology, 1973
N S, McNutt, R S, Weinstein
openaire   +2 more sources

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Corrigendum: Kinetic Measurements Reveal Enhanced Protein-Protein Interactions at Intercellular Junctions. [PDF]

Sci Rep, 2017
Shashikanth N, Kisting MA, Leckband DE.
europepmc   +1 more source