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Intercellular junctions in sepsis
Critical Care Medicine, 2008Intercellular junctions show important alterations in sepsis and in inflammatory states. It is hypotesized that their malfunction may be involved in vascular septic dysfunction and also in multiple organ dysfunction ...
SIRACUSANO, Luca, GIRASOLE, Viviana
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Intercellular junctions in myriapods
Tissue and Cell, 1990Tissue from the intestinal tract of myriapods, including millipedes, centipedes and pauropods were examined in tracer-impregnated sections and freeze-fracture replicas. The foregut and hindgut of all three classes exhibit pleated septate junctions; these display undulating intercellular ribbons in thin sections.
R, Dallai, E, Bigliardi, N J, Lane
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Intercellular junctions in human ependymomas
Acta Neuropathologica, 1972The ultrastructure and distribution of intercellular junctions in 5 human ependymomas of the fourth ventricle are described. The most common form was the simple apposition of cells with a cleft, about 200 A wide, between their cell membranes. The zonula adhaerens was predominant in cells near microvilli which were present along a widened intercellular ...
E, Tani, N, Higashi
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Intercellular junctions of rat endocardium
The Anatomical Record, 1975AbstractThe ultrastructure of the intercellular junctions of rat endocardium has been characterized following lanthanum exposure in vitro and uranyl acetate staining en bloc. The interendothelial clefts of the endocardium run either a relatively straight or convoluted course and possess one or two loci where the plasma membranes are in close apposition
P, Anversa, J, Giacomelli, J, Wiener
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Cell junctions and intercellular communication
In Vitro, 1980We have compared intercellular communication in normal and regenerating rat liver. Gap junctions are greatly reduced in size and numbers 29 to 35 hr after hepatectomy, but we still find some 90% of hepatocytes coupled by electrophysiological criteria.
J P, Revel +3 more
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Terbinafine inhibits gap junctional intercellular communication
Toxicology and Applied Pharmacology, 2016Terbinafine is an antifungal agent that selectively inhibits fungal sterol synthesis by blocking squalene epoxidase. We evaluated the effect of terbinafine on gap junctional intercellular communication (GJIC). Fluorescence recovery after photobleaching (FRAP) and I-YFP GJIC assays revealed that terbinafine inhibits GJIC in a reversible and dose ...
Ju Yeun, Lee +3 more
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Structure of gap junction intercellular channels
Current Opinion in Structural Biology, 1996Gap junctions are formed by a multigene family of polytopic membrane channel proteins, connexins, that have four hydrophobic transmembrane domains and their N and C termini located on the cytoplasmic membrane face. The C-terminal tail plays important roles in channel regulation by pH and phosphorylation.
M, Yeager, B J, Nicholson
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Assessment of Gap Junctional Intercellular Communication
Current Protocols in Toxicology, 2009AbstractGap junctions are important plasma membrane organelles through which most cells in normal tissues communicate with each other. They exist in two neighboring cells and each cell contributes half of the structure. One gap junction consists of two hexameric connexons that dock with each other to create a channel. Six of the basic subunits referred
James E, Klaunig, Yuhui, Shi
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Versican modulates gap junction intercellular communication
Journal of Cellular Physiology, 2007AbstractVersican is a large chondroitin sulfate proteoglycan and belongs to the family of lecticans. Versican possesses two globular domains, G1 and G3 domain, separated by a CS‐attachment region. The CS‐attachment region present in the middle region is divided into two spliced domains named CSα and β.
Wang, Sheng +4 more
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Isolation of intercellular junctions
1992Abstract Early electron microscopic studies revealed the existence of a number of distinct types of intercellular junctions. Specific physiological properties of a cell or tissue could often be correlated with the presence of a particular type of junction, suggesting very different functions for each type.
Elliot L Hertzberg +3 more
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