Results 91 to 100 of about 97,217 (382)
Switching to Biosimilars in Inflammatory Rheumatic Conditions: Current Knowledge
European Medical Journal Rheumatology, 2018 Biosimilars are more affordable versions of previously approved biopharmaceuticals that are designed to reduce healthcare expenditure and increase patient access to this therapeutic class. To achieve their economic potential, many European countries have
Filipe C. Araújo +2 more
doaj
Interchangeability of Fluconazole Drugs
Регуляторные исследования и экспертиза лекарственных средств, 2018 Fluconazole – an antifungal agent belonging to the chemical class of triazole derivatives – is represented in the Russian pharmaceutical market by a large number of generic drugs. An important issue of rational pharmacotherapy is the demonstration of the
N. D. Bunyatyan +3 more
doaj +1 more source
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
European Medical Journal, 2018 Switching patients from a reference to a biosimilar product has become a primary topic of interest, with different approaches being undertaken by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).
Anna La Noce, Marcin Ernst
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On the Computation of Local Interchangeability in Soft Constraint Satisfaction Problems [PDF]
Freuder in (1991) de?ned interchangeability for classical Constraint Satisfaction Problems (CSPs). Recently (2002), we extended the de?nition of interchangeability to Soft CSPs and we introduced two notions of relaxations based on degradation ?
Bistarelli, Stefano
core
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Focus on biosimilar etanercept – bioequivalence and interchangeability
Biologics: Targets & Therapy, 2018 Fabrizio Cantini,1 Maurizio Benucci2 1Department of Rheumatology, Hospital of Prato, Prato, Italy; 2Rheumatology Unit, Hospital S. Giovanni di Dio, Florence, Italy Background: The recent approval of reference etanercept (re-ETN) biosimilars SB4, GP2015 ...
Cantini F, Benucci M
doaj
LNG–Air Mixture as a Supplementary Energy Injection into a Biogas Distribution Network
Energies, 2017 Biogas production efficiency fluctuates with climate variations and agricultural arrangements, which pose a limiting factor upon its single supply to end users via a regional exclusive network, especially in peak demand.
Yang Zhou +4 more
doaj +1 more source
Toxins, 2020 Differences in botulinum neurotoxin manufacturing, formulation, and potency evaluation can impact dose and biological activity, which ultimately affect duration of action.
David Rupp +12 more
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Hyperfine-Grained Meanings in Classical Logic [PDF]
, 1991 This paper develops a semantics for a fragment of English that is based on the idea of `impossible possible worlds'. This idea has earlier been formulated by authors such as Montague, Cresswell, Hintikka, and Rantala, but the present set-up shows how it ...
Muskens, Reinhard
core +2 more sources