Results 101 to 110 of about 48,481 (274)
Biosimilars for Rheumatoid Arthritis: Riding the 2023 Wave [Podcast]
Open Access Rheumatology: Research and Reviews, 2023 Stanley B Cohen,1,* Mariah Z Leach2,* 1Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA; 2Mamas Facing Forward, Louisville, Colorado, USA*These authors contributed equally to this ...
Cohen SB, Leach MZ
doaj
Experimental Evaluation of Branching Schemes for the CSP
, 2010 The search strategy of a CP solver is determined by the variable and value ordering heuristics it employs and by the branching scheme it follows. Although the effects of variable and value ordering heuristics on search effort have been widely studied ...
Balafoutis, Thanasis +2 more
core
Efficient structural symmetry breaking for constraint satisfaction problems [PDF]
, 2007 Symmetry breaking for constraint satisfaction problems (CSPs) has attracted considerable attention in recent years. Various general schemes have been proposed to eliminate symmetries.
Flener, Pierre +4 more
core +1 more source
FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
SmallTalk: a novel small‐sized fusion tag for peptide expression and purification
FEBS Open Bio, EarlyView.The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.What factors make for an effective digital learning tool in Higher Education? This systematic review identifies elements of a digital tool that published examples reveal to be features of an engaging and impactful digital tool. A systematic literature search yielded 25 research papers for analysis.
Akmal Arzeman +4 more
wiley +1 more source
First-Order Decomposition Trees [PDF]
, 2013 Lifting attempts to speed up probabilistic inference by exploiting symmetries in the model. Exact lifted inference methods, like their propositional counterparts, work by recursively decomposing the model and the problem. In the propositional case, there
Blockeel, Hendrik +2 more
core
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
An Overview of Biosimilars—Development, Quality, Regulatory Issues, and Management in Healthcare
PharmaceuticalsBiological therapies have transformed high-burden treatments. As the patent and exclusivity period for biological medicines draws to a close, there is a possibility for the development and authorization of biosimilars.
Filipa Mascarenhas-Melo +8 more
doaj +1 more source