Results 101 to 110 of about 48,349 (272)

Comparative analysis of pachymetry and assessment of corneal topography in pediatric congenital corneal opacities: A study of AS-OCT and UBM imaging modalities

Indian Journal of Ophthalmology
This study aimed to assess the interchangeability of pachymetry measurements obtained by anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) in children with congenital corneal opacity (CCO).
Sonam Yangzes, Deeksha Sharma, Anchal Thakur, Jitender Jinagal, Sushmita Kaushik, Chintan Malhotra, Amit Gupta   +6 more
doaj   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Focus on biosimilar etanercept – bioequivalence and interchangeability

Biologics: Targets & Therapy, 2018
Fabrizio Cantini,1 Maurizio Benucci2 1Department of Rheumatology, Hospital of Prato, Prato, Italy; 2Rheumatology Unit, Hospital S. Giovanni di Dio, Florence, Italy Background: The recent approval of reference etanercept (re-ETN) biosimilars SB4, GP2015 ...
Cantini F, Benucci M
doaj  

Watertightness of window frames: experience of notified bodies [PDF]

, 2009
The research facility for testing building envelope elements at Ghent University has been testing the air- and watertightness of windows for over 30 years. As a certified lab a lot of tests are done for the industry according to standard procedures. This
Janssens, Arnold, Moens, Jan, Van Den Bossche, Nathan   +2 more
core   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Actual questions of clinical pharmacology by amlodipine: should we prefer the original or a generic drug?

КардиоСоматика, 2016
Selection of amlodipine (tablets) as a drug based on three basic criteria: clinical efficacy, safety / tolerability and quality is discussed below. The article deals with the successive stages of clinical pharmacology and pharmacotherapy from amlodipine ...
A. S Dukhanin
doaj  

Non-signaling protein therapeutics: a mechanism-based regulatory framework to modernize biosimilar development and global harmonization

Frontiers in Medicine
Non-Signaling Protein Therapeutics (NSPTs) represent a proposed regulatory category for biological products whose therapeutic effects operate through ligand neutralization, complement cascade blockade, or other non-signal-transducing mechanisms rather ...
Sarfaraz K. Niazi
doaj   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Switching from Reference to Biosimilar Products: An Overview of the European Approach and Real-World Experience So Far

European Medical Journal, 2018
Switching patients from a reference to a biosimilar product has become a primary topic of interest, with different approaches being undertaken by the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA).
Anna La Noce, Marcin Ernst
doaj  

Shuttle orbiter Ku-band radar/communications system design evaluation [PDF]

Tasks performed in an examination and critique of a Ku-band radar communications system for the shuttle orbiter are reported. Topics cover: (1) Ku-band high gain antenna/widebeam horn design evaluation; (2) evaluation of the Ku-band SPA and EA-1 LRU ...
Broad, P., Dodds, J., Holmes, J., Huth, G. K., Iwasaki, R., Maronde, R., Polydoros, A., Weber, C.   +7 more
core   +1 more source