Results 121 to 130 of about 97,217 (382)

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

Problems of interchangeability of systemic interferons for treatment of multiple sclerosis

open access: yesБезопасность и риск фармакотерапии, 2018
Problems of interchangeability of systemic interferons for treatment of multiple sclerosis are described. An analysis of 1,643 spontaneous reports existing in the Russian database for the period 2009 to 2015 was made in order to identify information on ...
I. I. Snegireva   +5 more
doaj  

Use of CR100 Scale for Session Rating of Perceived Exertion in Soccer and Its Interchangeability With the CR10.

open access: yesInternational Journal of Sports Physiology and Performance, 2016
PURPOSE To examine the construct validity of the session rating perceived exertion (s-RPE) assessed with the Borg CR100 scale to measure training loads in elite soccer and to examine if the CR100 is interchangeable and can provide more-accurate ratings ...
M. Fanchini   +5 more
semanticscholar   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

open access: yesFEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik   +3 more
wiley   +1 more source

Control of adverse drug reactions in HIV/AIDS antiretroviral treatment with interchangeable medicines

open access: yesБезопасность и риск фармакотерапии, 2018
Review on assessment data of ADR, which must be monitored during antiretroviral therapy in patients with HIV/AIDS are presented. Questions of drug safety acquire particular importance in conducting pharmacotherapy of the most socially significant ...
M. V. Zhuravleva   +5 more
doaj  

Protein O‐glycosylation in the Bacteroidota phylum

open access: yesFEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns   +2 more
wiley   +1 more source

Review of the literature on reference pricing [PDF]

open access: yes
This paper reviews the literature on reference pricing (RP) in pharmaceutical markets. The RP strategy for cost containment of expenditure on drugs is analyzed as part of the procurement mechanism.
Guillem López, Jaume Puig
core  

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

open access: yesFEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo   +4 more
wiley   +1 more source

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