Results 61 to 70 of about 139,403,014 (309)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Interest and effort in learning and performance
British Journal of Educational PsychologyAbstract Background Interest and effort are key motivational constructs in educational psychology, yet their interplay in learning remains underexplored. Building on Dewey's ( Interest and effort in education , 1913) view that ...
Laura Fink, Detlef Urhahne
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Vietnam Journal of Education, 2020 The course of Marxist-Leninist Philosophy, compulsory to all Vietnamese students, not only equips students with scientific knowledge but also a world view, humanity and thinking methodology.
Xuan Thanh Dinh
doaj
FEBS Letters, EarlyView.Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana +3 more
wiley +1 more source
Jurnal Pendidikan dan Kewirausahaan, 2021 Someone who has an interest in certain activities tends to pay great attention to these activities. Of course, in carrying out activities and efforts to achieve goals, there is a need for an impetus to foster the interest carried out by teachers, the ...
Ahmad Hafas Rasyidi, Minarsi Minarsi
doaj
FEBS Letters, EarlyView.Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley +1 more source
Economica, 2017 This study aimed to analyze: 1) the effect of the discipline of learning to the learning outcomes IPS eighth grade students at SMP N 4 Sutera South Coastal District, 2) effect of learning facilities to the learning outcomes IPS eighth grade students at ...
wela nurtia
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source