Results 71 to 80 of about 1,124,271 (267)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Konseling Kelompok dengan Teknik Behavioral untuk Meningkatkan Minat Belajar pada Siswa Slow Learner di Sekolah Dasar

Edukasia, 2023
The problem in this research is that it is limited to the group counseling model to increase interest in learning in slow learner students, while the aim is to describe the description of interest in learning and the effectiveness of the group ...
Amelia Atika, Novi Andriati
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Effectiveness of Using Gadgets on Students’ Learning Interests and Academic Performance

International Journal of Education and Teaching Zone
This quantitative study contributes to the literature by focusing on the increasing prevalence of technology in everyday life and the growing use of gadgets in educational settings.
Cherry Ann Madarcos, Mercy Grace De Vera, Maribeth Manlavi   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

The Effect of Stad Model (Student Teams Achievement Division) Assisted by Smart Treasure Promotional Tools on Learning Interest of Grade IV Elementary School Students

Jurnal PAJAR (Pendidikan dan Pengajaran)
This research is motivated by the lack of innovation in the application of learning models and teaching aids which causes low student interest in learning in the learning process in class IV of SD Negeri Wonorejo 03.
Intan Dwi Cahyani, Anni Malihatul Hawa
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Implementation of Project Based Learning on Students' Learning Interest and Understanding of Physics Concepts

JPFT (Jurnal Pendidikan Fisika dan Teknologi)
This research is pre-experimental research which aims to determine the increase in students' interest in learning and understanding of physics concepts after implementing the Project Based Learning (PjBL) model in physics subjects at SMA Negeri 1 Bone ...
Nurhaliza Baharuddin, Usman, Khaeruddin Khaeruddin, Trisno Setiawan   +3 more
doaj   +1 more source

Pengaruh Metode Pembelajaran Dan Minat Belajar Mahasiswa Terhadap Hasil Belajar Manajemen Konstruksi

Jurnal Teknologi Pendidikan, 2017
The purpose of this study is learning about learning and learning. This research method is method by designing treatment based on level 2x2. The data analysis technique used (anava) two lines, then continued with Tuckey test.
Rifana S.I Kawet
doaj   +1 more source