Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Supporting shape reinterpretation with eye tracking [PDF]
, 2011 It has been argued that reinterpretation is an essential process in design generation and idea exploration. However, computational design tools, such as computer-aided design systems, offer poor support for shape reinterpretation, and as such are not ...
Garner, Steven +4 more
core
Optical Modulation by Conducting Interfaces
, 2013 We analyze the interaction of a propagating guided electromagnetic wave with a quantum well embedded in a dielectric slab waveguide. First, we design a quantum well based on InAlGaAs compounds with the transition energy of 0.8eV corresponding to a ...
Karimi, Farhad, Khorasani, Sina
core +1 more source
Interpretation at the controller's edge: designing graphical user interfaces for the digital publication of the excavations at Gabii (Italy) [PDF]
, 2016 This paper discusses the authors’ approach to designing an interface for the Gabii Project’s digital volumes that attempts to fuse elements of traditional synthetic publications and site reports with rich digital datasets.
Johnson, Tyler D., Opitz, Rachel S.
core +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Don’t Make Me Type: A Study of Students’ Perceptions of Library Catalogues on Tablet Computers
Partnership: The Canadian Journal of Library and Information Practice and Research, 2015 The objective of this mixed methods pilot study was to ascertain university students’ perceptions of online library catalogues using tablet computers, to determine how the participants used tablets and whether or not the NEOS consortium catalogue (NEOS ...
Erik Gordon Christiansen
doaj +1 more source
Design of Hierarchical Nickel-Cobalt Phosphide/Nickel Oxide with Tunable Electronic Structure and Strong Chemical Interface for Advanced Supercapacitors [PDF]
, 2023 Gaini Zhang +9 more
openalex +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
‘Is this a vision? is this a dream?’: Finding New Dimensions in Shakespeare’s Texts
Digital Studies, 2005 None
Michael Best
doaj +1 more source
Towards a narrative-oriented framework for designing mathematical learning [PDF]
, 2004 This paper proposes a narrative-oriented approach to the design of educational activities, as well as a CSCL system to support them, in the context of learning mathematics. Both Mathematics and interface design seem unrelated to narrative.
Mor, Yishay, Noss, Richard
core +2 more sources