Results 71 to 80 of about 525,544 (263)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

DEPLOYMENT OF A DEEP LEARNING MODEL TO ASSIST PATHOLOGISTS WITH DONOR KIDNEY BIOPSY EVALUATION

open access: yesJournal of Pathology Informatics, 2022
Joseph Gaut   +5 more
doaj   +1 more source

Prototyping the Renaissance English Knowledgebase (REKn) and Professional Reading Environment (PReE), Past, Present, and Future Concerns: A Digital Humanities Project Narrative

open access: yesDigital Studies, 2010
The Renaissance English Knowledgebase (REKn) is an electronic knowledgebase consisting of primary and secondary materials (text, image, and audio) related to the Renaissance period.
Raymond Siemens
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Video Oyunlarındaki Arayüz Tasarımının Oyun Afişi Üzerindeki Yansımaları

open access: yesMedya ve Kültür, 2022
Bu çalışmada popüler ve başarılı video oyunlarının arayüz ve afiş tasarımları arasındaki bağın ortaya çıkarılması amaçlanmıştır. Arayüzler oyunun oynanabilmesi ve oyuncu ile bağ kurmayı sağladığı için çok önemlidir.
Hüdaver Altıntuğlu
doaj  

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

open access: yesFEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth   +6 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Supporting Sensemaking of Complex Objects with Visualizations: Visibility and Complementarity of Interactions

open access: yesInformatics, 2016
Making sense of complex objects is difficult, and typically requires the use of external representations to support cognitive demands while reasoning about the objects.
Kamran Sedig   +3 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy