Results 31 to 40 of about 525,544 (263)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
CAD at the design-manufacturing interface [PDF]
Proceedings of the 34th annual conference on Design automation conference - DAC '97, 1997 Owing to rapid changes of IC technologies, traditionaldesign rule checking is becoming inadequate to assure satisfactorylevels of IC manufacturability. This paper describes a newcomputer supported design analysis environment that improvesthe efficiency of manufacturability assessment of new products.This environment, called MAPEX 2, is described in the
Hans T. Heineken +5 more
openaire +1 more source
NanomaterialsThe selection of solvent is pivotal in liquid-phase exfoliation (LPE), as an ideal solvent minimizes the energy required to disrupt the interlayer attractive interactions while stabilizing exfoliated layers to prevent re-agglomeration.
Shunnian Wu +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Applied Sciences, 2022 Based on the individual traits of the user’s construal level differences, this study examines the visual cognition differences of graphic–text combined icon concreteness in the interface between users with high and low construal levels.
Yanfei Zhu +5 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Market user interface design [PDF]
Proceedings of the 13th ACM Conference on Electronic Commerce, 2012 Despite the pervasiveness of markets in our lives, little is known about the role of user interfaces (UIs) in promoting good decisions in market domains. How does the way we display market information to end users, and the set of choices we offer, influence users' decisions?
Seuken, Sven +5 more
openaire +2 more sources
Science and Technology of Nuclear Installations, 2014 Reliable information through instrumentation systems is essential in mitigating severe accidents such as the one that occurred at the Fukushima Daiichi nuclear power plant. There are five elements which might pose a potential threat to the reliability of
Min Yoo, Sung Min Shin, Hyun Gook Kang
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Advanced Materials InterfacesSputter‐deposited GaOx (i.e., oxygen‐deficient gallium oxide) films are evaluated as a potential replacement for the standard CdS buffer layers in Cu(In,Ga)Se2 (CIGSe) based thin‐film photovoltaics.
Donald Valenta +12 more
doaj +1 more source