Results 71 to 80 of about 2,350,921 (351)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Design and assessment of a virtual reality learning environment for firefighters

Frontiers in Computer Science
The use of virtual reality (VR) in firefighter training is promising because it provides cost-effective, safe environments that arouse similar behavioral responses to real-life scenarios.
Steven G. Wheeler, Simon Hoermann, Simon Hoermann, Stephan Lukosch, Robert W. Lindeman   +4 more
doaj   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Interface design for high energy density polymer nanocomposites [PDF]

, 2019
This review provides a detailed overview on the latest developments in the design and control of the interface in polymer based composite dielectrics for energy storage applications.
Bowen, Chris R., Chen, Sheng, Ellingford, Christopher, Luo, Hang, Wan, Chaoying, Zhang, Dou, Zhang, Yan, Zhou, Kechao, Zhou, Xuefan   +8 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Design assistance for user interface designers [PDF]

Proceedings of IEEE International Conference on Systems, Man and Cybernetics, 2002
The paper addresses a research approach in the area of user interface development tools, namely to discover the helpful, structured, and organised ways to integrate the use of guidelines, standards, and styles into the development tools. The aim of this research approach is to assist the user interface designer during the design process with the help ...
openaire   +2 more sources

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Designing a Semantically Rich Visual Iinterface for Cultural Digital Libraries Using the UNESCO Multilingual Thesaurus [PDF]

, 2010
This paper reports on the design of a visual user interface for the UNESCO digital portal. The interface makes use of the UNESCO multilingual thesaurus to provide visualized views of terms and their relationships and the way in which spaces associated ...
Bieber, Mark, Bouchard, Matthew, Fiorentino, Carlos, Ruecker, Stan, Shiri, Ali, Stafford, Amy   +5 more
core  

Optical Modulation by Conducting Interfaces

, 2013
We analyze the interaction of a propagating guided electromagnetic wave with a quantum well embedded in a dielectric slab waveguide. First, we design a quantum well based on InAlGaAs compounds with the transition energy of 0.8eV corresponding to a ...
Karimi, Farhad, Khorasani, Sina
core   +1 more source

Topological Insulators by Topology Optimization [PDF]

, 2019
An acoustic topological insulator (TI) is synthesized using topology optimization, a free material inverse design method. The TI appears spontaneously from the optimization process without imposing requirements on the existence of pseudo spin-1/2 states ...
Christiansen, Rasmus E., Sigmund, Ole, Wang, Fengwen   +2 more
core   +2 more sources