Results 91 to 100 of about 2,996,408 (334)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Tangible interfaces for download: initial observations from users' everyday environments
, 2010 Tangible user interfaces (TUIs) have been promoted and discussed in the HCI community for 15 years. Most reported TUIs are research prototypes, available in laboratories or museums. This paper reports an attempt to understand the impact of TUIs in users'
Shelley, Simon +4 more
core +1 more source
Signal averaging in cryogenic fast-field-cycling NMR experiments
Scientific ReportsThe spin-lattice relaxation time constant $$T_1$$ characterizes the equilibration of a spin system in a magnetic field with its environment, the lattice. Fast-field-cycling (FFC) relaxometry is dedicated to $$T_1$$ measurements at low field.
Michael Jurkutat +3 more
doaj +1 more source
Charging dynamics of an individual nanopore
Nature Communications, 2018 Modern energy-storage technologies are based on porous electrodes that store charge within nanometrically-narrow pores or slits. Here the authors show an approach to probe and measure, for the first time, the charging dynamics within an individual nano ...
Ran Tivony +4 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Publisher Correction: Charging dynamics of an individual nanopore
Nature Communications, 2019 The original version of this Article contained an error throughout in which an incorrect symbol was used for the diffusion coefficient: it should be cambria math, italicized, and not bold.
Ran Tivony +4 more
doaj +1 more source
Superconducting Interfaces Between Insulating Oxides
Science, 2007 At interfaces between complex oxides, electronic systems with unusual electronic properties can be generated. We report on superconductivity in the electron gas formed at the interface between two insulating dielectric perovskite oxides, LaAlO3 and ...
N. Reyren +13 more
semanticscholar +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Transforming graphical interfaces into auditory interfaces
Conference companion on Human factors in computing systems - CHI '95, 1995 This work explores transforming graphical interfaces into auditory interfaces. By transparently transforming graphical application written with a commercial toolkit, I have been able to investigate strategies for generically modeling graphical interfaces.
openaire +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source