Results 41 to 50 of about 236,190 (268)

Serum Levels of Interferon-γ, Interleukin-12 and Interleukin-8 in Patients with Brucellosis

AL-QADISIYAH MEDICAL JOURNAL, 2017
Background: Brucellosis is one of the most common bacterial zonosis. Different cytokines have an important role in the pathogenesis of the causative bacteria. Interferon-γ (IFN-γ) and interleukin-12 (IL-12) are among the most essential cytokines required for the elimination of infection with Brucella.Aims: The study aimed to measure serum levels of ...
openaire   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency

Emerging Infectious Diseases, 2017
We report a case of disseminated Mycobacterium genavense infection resulting from neutralizing anti–interferon-γ autoantibodies in the patient. We identified M. genavense targeting the hsp65 gene in an aspiration specimen of the lymph node.
Takanori Asakura, Ho Namkoong, Takuro Sakagami, Naoki Hasegawa, Kiyofumi Ohkusu, Akira Nakamura   +5 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

High level of anti-helicobacter pylori-heat shock protein 60II3, interferon-γ, and neopterin are risk factors of cardiovascular events in acute coronary syndrome patients

Bali Medical Journal, 2019
Background: Chronic inflammatory process that may cause acute myocardial infarction (AMI) has been known to play an important role in the pathogenesis of atherosclerosis and atheroma plaque instability. Based on inflammation process, several previous studies showed contradictory results in finding a relationship between infection H.
Anak Agung Wiradewi Lestari, I Wayan Wita, Ketut Suata, Ketut Suastika   +3 more
openaire   +1 more source

Investigation of the role of macrophages and endogenous interferon-γ in natural resistance of mice againstLegionella pneumophilainfection [PDF]

FEMS Microbiology Letters, 1992
Mice are highly resistant to Legionella pneumophila infection. To study the natural resistance, we used A/J and C57BL/6 mice which have macrophages permissive and non-permissive for the intracellular growth of L. pneumophila, respectively. The LD50 for A/J and C57BL/6 were 2.7 x 10(7) and 7.2 x 10(7) CFU, respectively, indicating that the difference in
H, Fujio, S, Yoshida, H, Miyamoto, M, Mitsuyama, Y, Mizuguchi   +4 more
openaire   +2 more sources

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Characterisation ofCandida albicansinfections of haematogenous and mucosal origin in mice lacking the interferon γ receptor protein [PDF]

FEMS Immunology & Medical Microbiology, 2000
Mice harbouring a null deletion mutation in the IFNgamma receptor gene were used to study the role of IFNgamma responsiveness during experimental systemic candidiasis of mucosal or haematogenous origin. After intravenous (i.v.) or intranasal (i.n.) challenge with Candida albicans the progression of infection and concomitant cellular and antibody anti-C.
L P, Londono, H B, Jones, A T, Vie, W L, McPheat, G, Booth, X M, Gao, G, Dougan   +6 more
openaire   +2 more sources

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Latticed Gold Nanoparticle Conjugation via Monomeric Streptavidin in Lateral Flow Assay for Detection of Autoantibody to Interferon-Gamma

Diagnostics, 2021
Adult-onset immunodeficiency syndrome (AOID) patients with autoantibodies (autoAbs) against interferon-gamma (IFN-γ) generally suffer from recurrent and recalcitrant disseminated non-tuberculous mycobacterial diseases.
Weeraya Thongkum, Umpa Yasamut, Koollawat Chupradit, Supachai Sakkhachornphop, Jiraprapa Wipasa, Kanokporn Sornsuwan, On-anong Juntit, Rawiwan Pornprasit, Wanwisa Thongkamwitoon, Jirapan Chaichanan, Jaruwan Khaoplab, Chonnikarn Chanpradab, Watchara Kasinrerk, Chatchai Tayapiwatana   +13 more
doaj   +1 more source